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Table 2 Positivity of different triage tests for histologically negative (No lesion), LSIL, HSIL, and CC

From: Evaluation of a methylation classifier for predicting pre-cancer lesion among women with abnormal results between HPV16/18 and cytology

 

No lesion (n = 60) % (95% CI)

LSIL (n = 107) % (95% CI)

(His)HSIL (n = 354) % (95% CI)

CC (n = 67) % (95% CI)

HPV16/18+

76.7 (67.7–79.8)

43.0 (39.8–45.7)

59.9 (54.1–64.2)

88.1 (83.2–95.4)

Cytology ≥(TCT)HSIL+

23.3 (19.8–26.4)

57.9 (54.2–60.1)

51.7 (45.9–56.8)

34.3 (28.0–36.1)

S5 at 2.85 cutoff

10.0 (7.6–13.8)

30.8 (27.9–35.0)

87.0 (84.3–89.7)

100

S5 at 3.7 cutoff

8.3 (3.2–13.9)

26.2 (20.2–31.8)

73.7 (69.8–77.6)

100

S5 at 0.8 cutoff

85.0 (77.9–89.4)

75.7 (69.9–78.8)

98.0 (92.4–99.7)

100

  1. No lesion histologically negative without squamous intraepithelial lesion, LSIL low-grade squamous intraepithelial lesion, (His)HSIL high-grade squamous intraepithelial lesion, CC cervical cancer, (TCT)HSIL+ cytological high-grade squamous intraepithelial lesion or worse