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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Dysregulation of 2-oxoglutarate-dependent dioxygenases by hyperglycaemia: does this link diabetes and vascular disease?

Fig. 6

Hyperglycaemia impairs adenosine monophosphate-activated protein kinase (AMPK)-mediated stabilisation of ten-eleven translocation (TET)2. a In peripheral blood mononuclear cells (PBMCs) from healthy controls, AMPK phosphorylates TET2 at serine 99, thereby stabilising it and increasing levels of its product, 5-hydroxymethylcytosine (5hmC). b Hyperglycaemia impairs AMPK mediated phosphorylation of TET2 in PBMCs from diabetic patients, leading to destabilisation and reduced activity of TET2

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