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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Dysregulation of 2-oxoglutarate-dependent dioxygenases by hyperglycaemia: does this link diabetes and vascular disease?

Fig. 5

Hyperglycaemia may influence ten-eleven translocation (TET)-dependent O-GlcNAcylation of the histone methyltransferase SET1/COMPASS complex. TET2 and TET3 interact with O-GlcNAc Transferase (OGT), promoting its O-GlcNAcylation of the SET1/COMPASS complex which mediates trimethylation of histone H3 lysine 4 (H3K4me3). Hyperglycaemia increases hexosamine pathway flux so increases production of the substrate UDP-GlcNAc. Abbreviations: glucose-6-phosphate (G6P), fructose-6-phosphate (F6P), fructose-1,6-bisphosphate (F1,6P2), glyceraldehyde-3-phosphate (G3P), 1,3-bisphosphoglycerate (1,3 BPG)

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