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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Dysregulation of 2-oxoglutarate-dependent dioxygenases by hyperglycaemia: does this link diabetes and vascular disease?

Fig. 3

Dysregulation of metabolites by hyperglycaemia. Hyperglycaemia has been reported to increase levels of lactate and succinate, which have been reported to decrease 2-oxoglutarate dependent dioxygenase (2-OGDD) activity. Increased flux through the tricarboxylic acid cycle may occur during hyperglycaemia, which could alter intracellular levels of 2-oxoglutarate, fumarate and succinate. High levels of 2-hydroxyglutarate (2HG), formed by the action of lactate dehydrogenase (LDH)-A on glutamine-derived 2-OG, or by mutant isocitrate dehydrogenase (IDH), is also reported to inhibit 2-OGDD activity. Abbreviations: glutamate dehydrogenase (GDH), glutaminase (GLS)

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