TY - JOUR AU - Zimmet, P. AU - Alberti, K. G. AU - Magliano, D. J. AU - Bennett, P. H. PY - 2016 DA - 2016// TI - Diabetes mellitus statistics on prevalence and mortality: facts and fallacies JO - Nat Rev Endocrinol VL - 12 UR - https://doi.org/10.1038/nrendo.2016.105 DO - 10.1038/nrendo.2016.105 ID - Zimmet2016 ER - TY - JOUR AU - Saeedi, P. AU - Petersohn, I. AU - Salpea, P. AU - Malanda, B. AU - Karuranga, S. AU - Unwin, N. PY - 2019 DA - 2019// TI - Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition JO - Diabetes Res Clin Pract VL - 157 UR - https://doi.org/10.1016/j.diabres.2019.107843 DO - 10.1016/j.diabres.2019.107843 ID - Saeedi2019 ER - TY - JOUR AU - Einarson, T. R. AU - Acs, A. AU - Ludwig, C. AU - Panton, U. H. PY - 2018 DA - 2018// TI - Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007-2017 JO - Cardiovasc Diabetol VL - 17 UR - https://doi.org/10.1186/s12933-018-0728-6 DO - 10.1186/s12933-018-0728-6 ID - Einarson2018 ER - TY - JOUR AU - Sallam, N. A. AU - Palmgren, V. A. C. AU - Singh, R. D. AU - John, C. M. AU - Thompson, J. A. PY - 2018 DA - 2018// TI - Programming of vascular dysfunction in the intrauterine milieu of diabetic pregnancies JO - Int J Mol Sci VL - 19 UR - https://doi.org/10.3390/ijms19113665 DO - 10.3390/ijms19113665 ID - Sallam2018 ER - TY - JOUR AU - Leybovitz-Haleluya, N. AU - Wainstock, T. AU - Landau, D. AU - Sheiner, E. PY - 2018 DA - 2018// TI - Maternal gestational diabetes mellitus and the risk of subsequent pediatric cardiovascular diseases of the offspring: a population-based cohort study with up to 18 years of follow up JO - Acta Diabetol VL - 55 UR - https://doi.org/10.1007/s00592-018-1176-1 DO - 10.1007/s00592-018-1176-1 ID - Leybovitz-Haleluya2018 ER - TY - JOUR AU - Moore, T. R. PY - 2010 DA - 2010// TI - Fetal exposure to gestational diabetes contributes to subsequent adult metabolic syndrome JO - Am J Obstet Gynecol VL - 202 UR - https://doi.org/10.1016/j.ajog.2010.02.059 DO - 10.1016/j.ajog.2010.02.059 ID - Moore2010 ER - TY - JOUR AU - Zheng, Y. AU - Ley, S. H. AU - Hu, F. B. PY - 2018 DA - 2018// TI - Global aetiology and epidemiology of type 2 diabetes mellitus and its complications JO - Nat Rev Endocrinol VL - 14 UR - https://doi.org/10.1038/nrendo.2017.151 DO - 10.1038/nrendo.2017.151 ID - Zheng2018 ER - TY - JOUR AU - Gaede, P. AU - Vedel, P. AU - Larsen, N. AU - Jensen, G. V. AU - Parving, H. H. P. O. PY - 2003 DA - 2003// TI - Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes JO - J Cardpulm Rehabil VL - 348 ID - Gaede2003 ER - TY - JOUR AU - Kannel, W. B. AU - McGee, D. L. PY - 1979 DA - 1979// TI - Diabetes and cardiovascular disease: the Framingham study JO - JAMA J Am Med Assoc VL - 241 UR - https://doi.org/10.1001/jama.1979.03290450033020 DO - 10.1001/jama.1979.03290450033020 ID - Kannel1979 ER - TY - JOUR AU - Ferranti, S. D. AU - Boer, I. H. AU - Fonseca, V. AU - Fox, C. S. AU - Golden, S. H. AU - Lavie, C. J. PY - 2014 DA - 2014// TI - Type 1 diabetes mellitus and cardiovascular disease a scientific statement from the american heart association andamerican diabetes association JO - Circulation VL - 130 UR - https://doi.org/10.1161/CIR.0000000000000034 DO - 10.1161/CIR.0000000000000034 ID - Ferranti2014 ER - TY - JOUR AU - Bonetti, P. O. AU - Lerman, L. O. AU - Lerman, A. PY - 2003 DA - 2003// TI - Endothelial dysfunction: a marker of atherosclerotic risk JO - Arterioscler Thromb Vasc Biol VL - 23 UR - https://doi.org/10.1161/01.ATV.0000051384.43104.FC DO - 10.1161/01.ATV.0000051384.43104.FC ID - Bonetti2003 ER - TY - JOUR AU - Sitia, S. AU - Tomasoni, L. AU - Atzeni, F. AU - Ambrosio, G. AU - Cordiano, C. AU - Catapano, A. PY - 2010 DA - 2010// TI - From endothelial dysfunction to atherosclerosis JO - Autoimmun Rev VL - 9 UR - https://doi.org/10.1016/j.autrev.2010.07.016 DO - 10.1016/j.autrev.2010.07.016 ID - Sitia2010 ER - TY - JOUR AU - Schalkwijk, C. G. AU - Stehouwer, C. D. A. PY - 2005 DA - 2005// TI - Vascular complications in diabetes mellitus: the role of endothelial dysfunction JO - Clin Sci VL - 109 UR - https://doi.org/10.1042/CS20050025 DO - 10.1042/CS20050025 ID - Schalkwijk2005 ER - TY - JOUR AU - Cai, H. AU - Harrison, D. G. PY - 2000 DA - 2000// TI - Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress JO - Circ Res VL - 87 UR - https://doi.org/10.1161/01.RES.87.10.840 DO - 10.1161/01.RES.87.10.840 ID - Cai2000 ER - TY - JOUR AU - Piga, R. AU - Naito, Y. AU - Kokura, S. AU - Handa, O. AU - Yoshikawa, T. PY - 2007 DA - 2007// TI - Short-term high glucose exposure induces monocyte-endothelial cells adhesion and transmigration by increasing VCAM-1 and MCP-1 expression in human aortic endothelial cells JO - Atherosclerosis VL - 193 UR - https://doi.org/10.1016/j.atherosclerosis.2006.09.016 DO - 10.1016/j.atherosclerosis.2006.09.016 ID - Piga2007 ER - TY - JOUR AU - Yu, C. H. AU - Suriguga, G. M. AU - Liu, W. J. AU - Cui, N. X. AU - Wang, Y. PY - 2017 DA - 2017// TI - High glucose induced endothelial to mesenchymal transition in human umbilical vein endothelial cell JO - Exp Mol Pathol VL - 102 UR - https://doi.org/10.1016/j.yexmp.2017.03.007 DO - 10.1016/j.yexmp.2017.03.007 ID - Yu2017 ER - TY - JOUR PY - 1993 DA - 1993// TI - The effect of intensive treatment of diabetes on the development and progression of long-term complications JO - N Engl J Med VL - 329 UR - https://doi.org/10.1056/NEJM199309303291401 DO - 10.1056/NEJM199309303291401 ID - ref17 ER - TY - JOUR PY - 1998 DA - 1998// TI - Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) JO - Lancet VL - 352 UR - https://doi.org/10.1016/S0140-6736(98)07019-6 DO - 10.1016/S0140-6736(98)07019-6 ID - ref18 ER - TY - JOUR AU - Bethel, M. A. AU - Neil, H. A. W. AU - Paul, S. K. AU - Matthews, D. R. AU - Holman, R. R. PY - 2008 DA - 2008// TI - 10-year follow-up of intensive glucose control in type 2 diabetes JO - N Engl J Med VL - 359 UR - https://doi.org/10.1056/NEJMoa0806470 DO - 10.1056/NEJMoa0806470 ID - Bethel2008 ER - TY - JOUR AU - Iwasaki, H. AU - Okamoto, R. AU - Kato, S. AU - Konishi, K. AU - Mizutani, H. AU - Yamada, N. PY - 2008 DA - 2008// TI - High glucose induces plasminogen activator inhibitor-1 expression through rho/rho-kinase-mediated NF-κB activation in bovine aortic endothelial cells JO - Atherosclerosis. VL - 196 UR - https://doi.org/10.1016/j.atherosclerosis.2006.12.025 DO - 10.1016/j.atherosclerosis.2006.12.025 ID - Iwasaki2008 ER - TY - JOUR AU - Srinivasan, S. AU - Hatley, M. E. AU - Bolick, D. T. AU - Palmer, L. A. AU - Edelstein, D. AU - Brownlee, M. PY - 2004 DA - 2004// TI - Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells JO - Diabetologia VL - 47 UR - https://doi.org/10.1007/s00125-004-1525-1 DO - 10.1007/s00125-004-1525-1 ID - Srinivasan2004 ER - TY - JOUR AU - Ho, F. M. AU - Liu, S. H. AU - Liau, C. S. AU - Huang, P. J. AU - Lin-Shiau, S. Y. PY - 2000 DA - 2000// TI - High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-JUN NH2-terminal kinase and caspase-3 JO - Circulation VL - 101 UR - https://doi.org/10.1161/01.CIR.101.22.2618 DO - 10.1161/01.CIR.101.22.2618 ID - Ho2000 ER - TY - JOUR AU - Engerman, R. L. AU - Kern, T. S. PY - 1987 DA - 1987// TI - Progression of incipient diabetic retinopathy during good glycemic control JO - Diabetes VL - 36 UR - https://doi.org/10.2337/diab.36.7.808 DO - 10.2337/diab.36.7.808 ID - Engerman1987 ER - TY - JOUR AU - Kowluru, R. A. PY - 2003 DA - 2003// TI - Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats JO - Diabetes VL - 52 UR - https://doi.org/10.2337/diabetes.52.3.818 DO - 10.2337/diabetes.52.3.818 ID - Kowluru2003 ER - TY - JOUR AU - Esposito, K. AU - Nappo, F. AU - Marfella, R. AU - Giugliano, G. AU - Giugliano, F. AU - Ciotola, M. PY - 2002 DA - 2002// TI - Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress JO - Circulation VL - 106 UR - https://doi.org/10.1161/01.CIR.0000034509.14906.AE DO - 10.1161/01.CIR.0000034509.14906.AE ID - Esposito2002 ER - TY - JOUR AU - Azcutia, V. AU - Abu-Taha, M. AU - Romacho, T. AU - Vázquez-Bella, M. AU - Matesanz, N. AU - Luscinskas, F. W. PY - 2010 DA - 2010// TI - Inflammation determines the pro-adhesive properties of high extracellular D-glucose in human endothelial cells in vitro and rat microvessels in vivo JO - PLoS One VL - 5 UR - https://doi.org/10.1371/journal.pone.0010091 DO - 10.1371/journal.pone.0010091 ID - Azcutia2010 ER - TY - JOUR AU - Zoungas, S. AU - Arima, H. AU - Gerstein, H. C. AU - Holman, R. R. AU - Woodward, M. AU - Reaven, P. PY - 2017 DA - 2017// TI - Effects of intensive glucose control on microvascular outcomes in patients with type 2 diabetes: a meta-analysis of individual participant data from randomised controlled trials JO - Lancet Diabetes Endocrinol VL - 5 UR - https://doi.org/10.1016/S2213-8587(17)30104-3 DO - 10.1016/S2213-8587(17)30104-3 ID - Zoungas2017 ER - TY - JOUR AU - Brownlee, M. PY - 2005 DA - 2005// TI - The pathobiology of diabetic complications: a unifying mechanism JO - Diabetes VL - 54 UR - https://doi.org/10.2337/diabetes.54.6.1615 DO - 10.2337/diabetes.54.6.1615 ID - Brownlee2005 ER - TY - JOUR AU - Brownlee, M. PY - 2001 DA - 2001// TI - Biochemistry and molecular cell biology of diabetic complications JO - Nature VL - 414 UR - https://doi.org/10.1038/414813a DO - 10.1038/414813a ID - Brownlee2001 ER - TY - JOUR AU - Nishikawa, T. AU - Edelstein, D. AU - Du, X. L. AU - Yamagishi, S. I. AU - Matsumura, T. AU - Kaneda, Y. PY - 2000 DA - 2000// TI - Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage JO - Nature VL - 404 UR - https://doi.org/10.1038/35008121 DO - 10.1038/35008121 ID - Nishikawa2000 ER - TY - JOUR AU - Ling, C. AU - Groop, L. PY - 2009 DA - 2009// TI - Epigenetics: a molecular link between environmental factors and type 2 diabetes JO - Diabetes VL - 58 UR - https://doi.org/10.2337/db09-1003 DO - 10.2337/db09-1003 ID - Ling2009 ER - TY - JOUR AU - Zarzour, A. AU - Kim, H. W. AU - Weintraub, N. L. PY - 2019 DA - 2019// TI - Epigenetic regulation of vascular diseases JO - Arterioscler Thromb Vasc Biol VL - 39 UR - https://doi.org/10.1161/ATVBAHA.119.312193 DO - 10.1161/ATVBAHA.119.312193 ID - Zarzour2019 ER - TY - JOUR AU - Pirola, L. AU - Balcerczyk, A. AU - Okabe, J. AU - El-Osta, A. PY - 2010 DA - 2010// TI - Epigenetic phenomena linked to diabetic complications JO - Nat Rev Endocrinol. VL - 6 UR - https://doi.org/10.1038/nrendo.2010.188 DO - 10.1038/nrendo.2010.188 ID - Pirola2010 ER - TY - JOUR AU - Pasquier, J. AU - Hoarau-Véchot, J. AU - Fakhro, K. AU - Rafii, A. AU - Abi, K. C. PY - 2015 DA - 2015// TI - Epigenetics and cardiovascular disease in diabetes JO - Curr Diab Rep VL - 118 ID - Pasquier2015 ER - TY - JOUR AU - Othman, S. H. PY - 2019 DA - 2019// TI - The epigenetics of diabetes, obesity, overweight and cardiovascular disease JO - AIMS Genet VL - 6 UR - https://doi.org/10.3934/genet.2019.3.36 DO - 10.3934/genet.2019.3.36 ID - Othman2019 ER - TY - JOUR AU - Rodriguez-Araujo, G. AU - Nakagami, H. PY - 2018 DA - 2018// TI - Pathophysiology of cardiovascular disease in diabetes mellitus JO - Cardiovasc Endocrinol Metab VL - 7 UR - https://doi.org/10.1097/XCE.0000000000000141 DO - 10.1097/XCE.0000000000000141 ID - Rodriguez-Araujo2018 ER - TY - JOUR AU - Rosa, S. AU - Arcidiacono, B. AU - Chiefari, E. AU - Brunetti, A. AU - Indolfi, C. AU - Foti, D. P. PY - 2018 DA - 2018// TI - Type 2 diabetes mellitus and cardiovascular disease: genetic and epigenetic links JO - Front Endocrinol (Lausanne) VL - 9 UR - https://doi.org/10.3389/fendo.2018.00002 DO - 10.3389/fendo.2018.00002 ID - Rosa2018 ER - TY - JOUR AU - Pirola, L. AU - Balcerczyk, A. AU - Tothill, R. W. AU - Haviv, I. AU - Kaspi, A. AU - Lunke, S. PY - 2011 DA - 2011// TI - Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells JO - Genome Res VL - 21 UR - https://doi.org/10.1101/gr.116095.110 DO - 10.1101/gr.116095.110 ID - Pirola2011 ER - TY - JOUR AU - Johnson, C. AU - Warmoes, M. O. AU - Shen, X. AU - Locasale, J. W. PY - 2015 DA - 2015// TI - Epigenetics and cancer metabolism JO - Cancer Lett VL - 356 UR - https://doi.org/10.1016/j.canlet.2013.09.043 DO - 10.1016/j.canlet.2013.09.043 ID - Johnson2015 ER - TY - JOUR AU - Donohoe, D. R. AU - Bultman, S. J. PY - 2012 DA - 2012// TI - Metaboloepigenetics: interrelationships between energy metabolism and epigenetic control of gene expression JO - J Cell Physiol VL - 227 UR - https://doi.org/10.1002/jcp.24054 DO - 10.1002/jcp.24054 ID - Donohoe2012 ER - TY - JOUR AU - Stratton, M. S. AU - Farina, F. M. AU - Elia, L. PY - 2019 DA - 2019// TI - Epigenetics and vascular diseases JO - J Mol Cell Cardiol VL - 133 UR - https://doi.org/10.1016/j.yjmcc.2019.06.010 DO - 10.1016/j.yjmcc.2019.06.010 ID - Stratton2019 ER - TY - JOUR AU - Okano, M. AU - Bell, D. W. AU - Haber, D. A. AU - Li, E. PY - 1999 DA - 1999// TI - DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development JO - Cell VL - 99 UR - https://doi.org/10.1016/S0092-8674(00)81656-6 DO - 10.1016/S0092-8674(00)81656-6 ID - Okano1999 ER - TY - JOUR AU - Li, E. AU - Bestor, T. H. AU - Jaenisch, R. PY - 1992 DA - 1992// TI - Targeted mutation of the DNA methyltransferase gene results in embryonic lethality JO - Cell VL - 69 UR - https://doi.org/10.1016/0092-8674(92)90611-F DO - 10.1016/0092-8674(92)90611-F ID - Li1992 ER - TY - JOUR AU - Subramaniam, D. AU - Thombre, R. AU - Dhar, A. AU - Anant, S. PY - 2014 DA - 2014// TI - DNA methyltransferases: a novel target for prevention and therapy JO - Front Oncol VL - 4 UR - https://doi.org/10.3389/fonc.2014.00080 DO - 10.3389/fonc.2014.00080 ID - Subramaniam2014 ER - TY - JOUR AU - Siegfried, Z. AU - Cedar, H. PY - 1997 DA - 1997// TI - DNA methylation: a molecular lock JO - Curr Biol VL - 7 UR - https://doi.org/10.1016/S0960-9822(06)00144-8 DO - 10.1016/S0960-9822(06)00144-8 ID - Siegfried1997 ER - TY - STD TI - Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (80- ). 2009;324(5929):930–5. ID - ref46 ER - TY - JOUR AU - Sun, M. AU - Song, M. M. AU - Wei, B. AU - Gao, Q. AU - Li, L. AU - Yao, B. PY - 2016 DA - 2016// TI - 5-Hydroxymethylcytosine-mediated alteration of transposon activity associated with the exposure to adverse in utero environments in human JO - Hum Mol Genet VL - 25 UR - https://doi.org/10.1093/hmg/ddw089 DO - 10.1093/hmg/ddw089 ID - Sun2016 ER - TY - STD TI - Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, et al. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (80- ). 2011;333(6047):1300–3. ID - ref48 ER - TY - JOUR AU - Song, C. X. AU - He, C. PY - 2013 DA - 2013// TI - Potential functional roles of DNA demethylation intermediates JO - Trends Biochem Sci VL - 38 UR - https://doi.org/10.1016/j.tibs.2013.07.003 DO - 10.1016/j.tibs.2013.07.003 ID - Song2013 ER - TY - JOUR AU - Song, C. X. AU - Szulwach, K. E. AU - Dai, Q. AU - Fu, Y. AU - Mao, S. Q. AU - Lin, L. PY - 2013 DA - 2013// TI - Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming JO - Cell VL - 153 UR - https://doi.org/10.1016/j.cell.2013.04.001 DO - 10.1016/j.cell.2013.04.001 ID - Song2013 ER - TY - JOUR AU - Yu, M. AU - Hon, G. C. AU - Szulwach, K. E. AU - Song, C. X. AU - Zhang, L. AU - Kim, A. PY - 2012 DA - 2012// TI - Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome JO - Cell. VL - 149 UR - https://doi.org/10.1016/j.cell.2012.04.027 DO - 10.1016/j.cell.2012.04.027 ID - Yu2012 ER - TY - JOUR AU - Spruijt, C. G. AU - Gnerlich, F. AU - Smits, A. H. AU - Pfaffeneder, T. AU - Jansen, P. W. T. C. AU - Bauer, C. PY - 2013 DA - 2013// TI - Dynamic readers for 5-(Hydroxy)methylcytosine and its oxidized derivatives JO - Cell VL - 152 UR - https://doi.org/10.1016/j.cell.2013.02.004 DO - 10.1016/j.cell.2013.02.004 ID - Spruijt2013 ER - TY - JOUR AU - Kellinger, M. W. AU - Song, C. X. AU - Chong, J. AU - Lu, X. Y. AU - He, C. AU - Wang, D. PY - 2012 DA - 2012// TI - 5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription JO - Nat Struct Mol Biol VL - 19 UR - https://doi.org/10.1038/nsmb.2346 DO - 10.1038/nsmb.2346 ID - Kellinger2012 ER - TY - JOUR AU - Hübner, M. R. AU - Eckersley-Maslin, M. A. AU - Spector, D. L. PY - 2013 DA - 2013// TI - Chromatin organization and transcriptional regulation JO - Curr Opin Genet Dev VL - 23 UR - https://doi.org/10.1016/j.gde.2012.11.006 DO - 10.1016/j.gde.2012.11.006 ID - Hübner2013 ER - TY - JOUR AU - Schiattarella, G. G. AU - Madonna, R. AU - Linthout, S. AU - Thum, T. AU - Schulz, R. AU - Ferdinandy, P. PY - 2018 DA - 2018// TI - Epigenetic modulation of vascular diseases: assessing the evidence and exploring the opportunities JO - Vasc Pharmacol VL - 107 UR - https://doi.org/10.1016/j.vph.2018.02.009 DO - 10.1016/j.vph.2018.02.009 ID - Schiattarella2018 ER - TY - JOUR AU - Saksouk, N. AU - Simboeck, E. AU - Déjardin, J. PY - 2015 DA - 2015// TI - Constitutive heterochromatin formation and transcription in mammals JO - Epigenetics and Chromatin VL - 8 UR - https://doi.org/10.1186/1756-8935-8-3 DO - 10.1186/1756-8935-8-3 ID - Saksouk2015 ER - TY - JOUR AU - Bannister, A. J. AU - Kouzarides, T. PY - 2011 DA - 2011// TI - Regulation of chromatin by histone modifications JO - Cell Res VL - 21 UR - https://doi.org/10.1038/cr.2011.22 DO - 10.1038/cr.2011.22 ID - Bannister2011 ER - TY - JOUR AU - Youn, H. D. PY - 2017 DA - 2017// TI - Methylation and demethylation of DNA and histones in chromatin: the most complicated epigenetic marker JO - Exp Mol Med VL - 49 UR - https://doi.org/10.1038/emm.2017.38 DO - 10.1038/emm.2017.38 ID - Youn2017 ER - TY - JOUR AU - Black, J. C. AU - Rechem, C. AU - Whetstine, J. R. PY - 2012 DA - 2012// TI - Histone lysine methylation dynamics: establishment, regulation, and biological impact JO - Mol Cell VL - 48 UR - https://doi.org/10.1016/j.molcel.2012.11.006 DO - 10.1016/j.molcel.2012.11.006 ID - Black2012 ER - TY - JOUR AU - Anand, R. AU - Marmorstein, R. PY - 2007 DA - 2007// TI - Structure and mechanism of lysine-specific demethylase enzymes JO - J Biol Chem VL - 282 UR - https://doi.org/10.1074/jbc.R700027200 DO - 10.1074/jbc.R700027200 ID - Anand2007 ER - TY - JOUR AU - Klose, R. J. AU - Kallin, E. M. AU - Zhang, Y. PY - 2006 DA - 2006// TI - JmjC-domain-containing proteins and histone demethylation JO - Nat Rev Genet VL - 7 UR - https://doi.org/10.1038/nrg1945 DO - 10.1038/nrg1945 ID - Klose2006 ER - TY - JOUR AU - Pollard, P. AU - Yang, M. AU - Su, H. AU - Soga, T. AU - Kranc, K. PY - 2014 DA - 2014// TI - Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism JO - Hypoxia VL - 2 UR - https://doi.org/10.2147/HP.S47968 DO - 10.2147/HP.S47968 ID - Pollard2014 ER - TY - JOUR AU - Schofield, C. J. AU - Ratcliffe, P. J. PY - 2004 DA - 2004// TI - Oxygen sensing by HIF hydroxylases JO - Nat Rev Mol Cell Biol VL - 5 UR - https://doi.org/10.1038/nrm1366 DO - 10.1038/nrm1366 ID - Schofield2004 ER - TY - JOUR AU - Keeley, T. P. AU - Mann, G. E. PY - 2019 DA - 2019// TI - Defining physiological normoxia for improved translation of cell physiology to animal models and humans JO - Physiol Rev VL - 99 UR - https://doi.org/10.1152/physrev.00041.2017 DO - 10.1152/physrev.00041.2017 ID - Keeley2019 ER - TY - JOUR AU - Bierhansl, L. AU - Conradi, L. -. C. AU - Treps, L. AU - Dewerchin, M. AU - Carmeliet, P. PY - 2017 DA - 2017// TI - Central role of metabolism in endothelial cell function and vascular disease JO - Physiology VL - 32 UR - https://doi.org/10.1152/physiol.00031.2016 DO - 10.1152/physiol.00031.2016 ID - Bierhansl2017 ER - TY - JOUR AU - Pircher, A. AU - Treps, L. AU - Bodrug, N. AU - Carmeliet, P. PY - 2016 DA - 2016// TI - Endothelial cell metabolism: a novel player in atherosclerosis? Basic principles and therapeutic opportunities JO - Atherosclerosis VL - 253 UR - https://doi.org/10.1016/j.atherosclerosis.2016.08.011 DO - 10.1016/j.atherosclerosis.2016.08.011 ID - Pircher2016 ER - TY - JOUR AU - Taylor, C. T. PY - 2008 DA - 2008// TI - Mitochondria and cellular oxygen sensing in the HIF pathway JO - Biochem J VL - 409 UR - https://doi.org/10.1042/BJ20071249 DO - 10.1042/BJ20071249 ID - Taylor2008 ER - TY - JOUR AU - Watson, R. T. AU - Pessin, J. E. PY - 2001 DA - 2001// TI - Intracellular organization of insulin signaling and GLUT4 translocation JO - Recent Prog Horm Res VL - 56 UR - https://doi.org/10.1210/rp.56.1.175 DO - 10.1210/rp.56.1.175 ID - Watson2001 ER - TY - JOUR AU - Artwohl, M. AU - Brunmair, B. AU - Fürnsinn, C. AU - Hölzenbein, T. AU - Rainer, G. AU - Freudenthaler, A. PY - 2007 DA - 2007// TI - Insulin does not regulate glucose transport and metabolism in human endothelium JO - Eur J Clin Investig VL - 37 UR - https://doi.org/10.1111/j.1365-2362.2007.01838.x DO - 10.1111/j.1365-2362.2007.01838.x ID - Artwohl2007 ER - TY - JOUR AU - Dobrina, A. AU - Rossi, F. PY - 1983 DA - 1983// TI - Metabolic properties of freshly isolated bovine endothelial cells JO - Biochim Biophys Acta VL - 762 UR - https://doi.org/10.1016/0167-4889(83)90084-8 DO - 10.1016/0167-4889(83)90084-8 ID - Dobrina1983 ER - TY - JOUR AU - Selva, M. AU - Beltramo, E. AU - Pagnozzi, F. AU - Bena, E. AU - Molinatti, P. A. AU - Molinatti, G. M. PY - 1996 DA - 1996// TI - Thiamine corrects delayed replication and decreases production of lactate and advanced glycation end-products in bovine retinal and human umbilical vein endothelial cells cultured under high glucose conditions JO - Diabetologia VL - 39 UR - https://doi.org/10.1007/s001250050568 DO - 10.1007/s001250050568 ID - Selva1996 ER - TY - JOUR AU - Ido, Y. AU - Carling, D. AU - Ruderman, N. PY - 2002 DA - 2002// TI - Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells JO - Diabetes VL - 51 UR - https://doi.org/10.2337/diabetes.51.1.159 DO - 10.2337/diabetes.51.1.159 ID - Ido2002 ER - TY - JOUR AU - Sada, K. AU - Nishikawa, T. AU - Kukidome, D. AU - Yoshinaga, T. AU - Kajihara, N. AU - Sonoda, K. PY - 2016 DA - 2016// TI - Hyperglycemia induces cellular hypoxia through production of mitochondrial ROS followed by suppression of aquaporin-1 JO - PLoS One VL - 11 UR - https://doi.org/10.1371/journal.pone.0158619 DO - 10.1371/journal.pone.0158619 ID - Sada2016 ER - TY - JOUR AU - Bensellam, M. AU - Duvillié, B. AU - Rybachuk, G. AU - Laybutt, D. R. AU - Magnan, C. AU - Guiot, Y. PY - 2012 DA - 2012// TI - Glucose-induced O 2 consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0029807 DO - 10.1371/journal.pone.0029807 ID - Bensellam2012 ER - TY - JOUR AU - Gerber, P. A. AU - Rutter, G. A. PY - 2017 DA - 2017// TI - The role of oxidative stress and hypoxia in pancreatic beta-cell dysfunction in diabetes mellitus JO - Antioxidants Redox Signal VL - 26 UR - https://doi.org/10.1089/ars.2016.6755 DO - 10.1089/ars.2016.6755 ID - Gerber2017 ER - TY - JOUR AU - Nyengaard, J. R. AU - Ido, Y. AU - Kilo, C. AU - Williamson, J. R. PY - 2004 DA - 2004// TI - Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy JO - Diabetes VL - 53 UR - https://doi.org/10.2337/diabetes.53.11.2931 DO - 10.2337/diabetes.53.11.2931 ID - Nyengaard2004 ER - TY - JOUR AU - Capla, J. M. AU - Grogan, R. H. AU - Callaghan, M. J. AU - Galiano, R. D. AU - Tepper, O. M. AU - Ceradini, D. J. PY - 2007 DA - 2007// TI - Diabetes impairs endothelial progenitor cell-mediated blood vessel formation in response to hypoxia JO - Plast Reconstr Surg VL - 119 UR - https://doi.org/10.1097/01.prs.0000244830.16906.3f DO - 10.1097/01.prs.0000244830.16906.3f ID - Capla2007 ER - TY - JOUR AU - Hancock, R. L. AU - Masson, N. AU - Dunne, K. AU - Flashman, E. AU - Kawamura, A. PY - 2017 DA - 2017// TI - The activity of JmjC histone lysine demethylase KDM4A is highly sensitive to oxygen concentrations JO - ACS Chem Biol VL - 12 UR - https://doi.org/10.1021/acschembio.6b00958 DO - 10.1021/acschembio.6b00958 ID - Hancock2017 ER - TY - JOUR AU - Thienpont, B. AU - Steinbacher, J. AU - Zhao, H. AU - D’Anna, F. AU - Kuchnio, A. AU - Ploumakis, A. PY - 2016 DA - 2016// TI - Tumour hypoxia causes DNA hypermethylation by reducing TET activity JO - Nature VL - 537 UR - https://doi.org/10.1038/nature19081 DO - 10.1038/nature19081 ID - Thienpont2016 ER - TY - JOUR AU - Sánchez-Fernández, E. M. AU - Tarhonskaya, H. AU - Al-Qahtani, K. AU - Hopkinson, R. J. AU - Mccullagh, J. S. O. AU - Schofield, C. J. PY - 2013 DA - 2013// TI - Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase JO - Biochem J VL - 449 UR - https://doi.org/10.1042/BJ20121155 DO - 10.1042/BJ20121155 ID - Sánchez-Fernández2013 ER - TY - JOUR AU - Burr, S. AU - Caldwell, A. AU - Chong, M. AU - Beretta, M. AU - Metcalf, S. AU - Hancock, M. PY - 2018 DA - 2018// TI - Oxygen gradients can determine epigenetic asymmetry and cellular differentiation viadifferential regulation of Tet activity in embryonic stem cells JO - Nucleic Acids Res VL - 46 UR - https://doi.org/10.1093/nar/gkx1197 DO - 10.1093/nar/gkx1197 ID - Burr2018 ER - TY - JOUR AU - Dobrynin, G. AU - McAllister, T. E. AU - Leszczynska, K. B. AU - Ramachandran, S. AU - Krieg, A. J. AU - Kawamura, A. PY - 2017 DA - 2017// TI - KDM4A regulates HIF-1 levels through H3K9me3 JO - Sci Rep VL - 7 UR - https://doi.org/10.1038/s41598-017-11658-3 DO - 10.1038/s41598-017-11658-3 ID - Dobrynin2017 ER - TY - STD TI - Batie M, Frost J, Frost M, Wilson JW, Schofield P, Rocha S. Hypoxia induces rapid changes to histone methylation and reprograms chromatin. Science (80- ). 2019;363(6432):1222–6. ID - ref83 ER - TY - JOUR AU - Melvin, A. AU - Rocha, S. PY - 2012 DA - 2012// TI - Chromatin as an oxygen sensor and active player in the hypoxia response JO - Cell Signal VL - 24 UR - https://doi.org/10.1016/j.cellsig.2011.08.019 DO - 10.1016/j.cellsig.2011.08.019 ID - Melvin2012 ER - TY - JOUR AU - Tsai, Y. P. AU - Chen, H. F. AU - Chen, S. Y. AU - Cheng, W. C. AU - Wang, H. W. AU - Shen, Z. J. PY - 2014 DA - 2014// TI - TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator JO - Genome Biol VL - 15 UR - https://doi.org/10.1186/s13059-014-0513-0 DO - 10.1186/s13059-014-0513-0 ID - Tsai2014 ER - TY - JOUR AU - Muecke, C. AU - Dabral, S. AU - Seeger, W. AU - Pullamsetti, S. S. PY - 2016 DA - 2016// TI - Role and regulation of Jumonji C domain-containing histone demethylases 1A and 2B in pulmonary hypertension JO - Eur Respir J VL - 48 ID - Muecke2016 ER - TY - JOUR AU - Krieg, A. J. AU - Rankin, E. B. AU - Chan, D. AU - Razorenova, O. AU - Fernandez, S. AU - Giaccia, A. J. PY - 2010 DA - 2010// TI - Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 enhances hypoxic gene expression and tumor growth JO - Mol Cell Biol VL - 30 UR - https://doi.org/10.1128/MCB.00444-09 DO - 10.1128/MCB.00444-09 ID - Krieg2010 ER - TY - JOUR AU - Yang, H. AU - Lin, H. AU - Xu, H. AU - Zhang, L. AU - Cheng, L. AU - Wen, B. PY - 2014 DA - 2014// TI - TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites JO - Cell Res VL - 24 UR - https://doi.org/10.1038/cr.2014.81 DO - 10.1038/cr.2014.81 ID - Yang2014 ER - TY - JOUR AU - Xiao, M. AU - Yang, H. AU - Xu, W. AU - Ma, S. AU - Lin, H. AU - Zhu, H. PY - 2012 DA - 2012// TI - Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors JO - Genes Dev VL - 26 UR - https://doi.org/10.1101/gad.191056.112 DO - 10.1101/gad.191056.112 ID - Xiao2012 ER - TY - JOUR AU - Lu, X. AU - Zhao, B. S. AU - He, C. PY - 2015 DA - 2015// TI - TET family proteins: oxidation activity, interacting molecules, and functions in diseases JO - Chem Rev VL - 115 UR - https://doi.org/10.1021/cr500470n DO - 10.1021/cr500470n ID - Lu2015 ER - TY - JOUR AU - Addabbo, F. AU - Ratliff, B. AU - Park, H. C. AU - Kuo, M. C. AU - Ungvari, Z. AU - Ciszar, A. PY - 2009 DA - 2009// TI - The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach JO - Am J Pathol VL - 174 UR - https://doi.org/10.2353/ajpath.2009.080650 DO - 10.2353/ajpath.2009.080650 ID - Addabbo2009 ER - TY - JOUR AU - Koziel, A. AU - Woyda-Ploszczyca, A. AU - Kicinska, A. AU - Jarmuszkiewicz, W. PY - 2012 DA - 2012// TI - The influence of high glucose on the aerobic metabolism of endothelial EA.hy926 cells JO - Pflugers Arch Eur J Physiol VL - 464 UR - https://doi.org/10.1007/s00424-012-1156-1 DO - 10.1007/s00424-012-1156-1 ID - Koziel2012 ER - TY - JOUR AU - Alarcon, C. AU - Wicksteed, B. AU - Prentki, M. AU - Corkey, B. E. AU - Rhodes, C. J. PY - 2002 DA - 2002// TI - Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation JO - Diabetes VL - 51 UR - https://doi.org/10.2337/diabetes.51.8.2496 DO - 10.2337/diabetes.51.8.2496 ID - Alarcon2002 ER - TY - JOUR AU - Xu, W. AU - Yang, H. AU - Liu, Y. AU - Yang, Y. AU - Wang, P. AU - Kim, S. H. PY - 2011 DA - 2011// TI - Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases JO - Cancer Cell VL - 19 UR - https://doi.org/10.1016/j.ccr.2010.12.014 DO - 10.1016/j.ccr.2010.12.014 ID - Xu2011 ER - TY - JOUR AU - Chowdhury, R. AU - Yeoh, K. K. AU - Tian, Y. M. AU - Hillringhaus, L. AU - Bagg, E. A. AU - Rose, N. R. PY - 2011 DA - 2011// TI - The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases JO - EMBO Rep VL - 12 UR - https://doi.org/10.1038/embor.2011.43 DO - 10.1038/embor.2011.43 ID - Chowdhury2011 ER - TY - JOUR AU - Koivunen, P. AU - Lee, S. AU - Duncan, C. G. AU - Lopez, G. AU - Lu, G. AU - Ramkissoon, S. PY - 2012 DA - 2012// TI - Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation JO - Nature VL - 483 UR - https://doi.org/10.1038/nature10898 DO - 10.1038/nature10898 ID - Koivunen2012 ER - TY - JOUR AU - Lu, C. AU - Ward, P. S. AU - Kapoor, G. S. AU - Rohle, D. AU - Turcan, S. AU - Abdel-Wahab, O. PY - 2012 DA - 2012// TI - IDH mutation impairs histone demethylation and results in a block to cell differentiation JO - Nature VL - 483 UR - https://doi.org/10.1038/nature10860 DO - 10.1038/nature10860 ID - Lu2012 ER - TY - JOUR AU - Linster, C. L. AU - Schaftingen, E. AU - Hanson, A. D. PY - 2013 DA - 2013// TI - Metabolite damage and its repair or pre-emption JO - Nat Chem Biol VL - 9 UR - https://doi.org/10.1038/nchembio.1141 DO - 10.1038/nchembio.1141 ID - Linster2013 ER - TY - JOUR AU - Ward, P. S. AU - Patel, J. AU - Wise, D. R. AU - Abdel-Wahab, O. AU - Bennett, B. D. AU - Coller, H. A. PY - 2010 DA - 2010// TI - The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting α-ketoglutarate to 2-hydroxyglutarate JO - Cancer Cell VL - 17 UR - https://doi.org/10.1016/j.ccr.2010.01.020 DO - 10.1016/j.ccr.2010.01.020 ID - Ward2010 ER - TY - JOUR AU - Intlekofer, A. M. AU - DeMatteo, R. G. AU - Venneti, S. AU - Finley, L. W. S. AU - Lu, C. AU - Judkins, A. R. PY - 2015 DA - 2015// TI - Hypoxia induces production of L-2-hydroxyglutarate JO - Cell Metab VL - 22 UR - https://doi.org/10.1016/j.cmet.2015.06.023 DO - 10.1016/j.cmet.2015.06.023 ID - Intlekofer2015 ER - TY - JOUR AU - Teng, X. AU - Emmett, M. J. AU - Lazar, M. A. AU - Goldberg, E. AU - Rabinowitz, J. D. PY - 2016 DA - 2016// TI - Lactate dehydrogenase C produces S-2-hydroxyglutarate in mouse testis JO - ACS Chem Biol VL - 11 UR - https://doi.org/10.1021/acschembio.6b00290 DO - 10.1021/acschembio.6b00290 ID - Teng2016 ER - TY - JOUR AU - Gillies, R. J. AU - Pilot, C. AU - Marunaka, Y. AU - Fais, S. PY - 2019 DA - 2019// TI - Targeting acidity in cancer and diabetes JO - Biochim Biophys Acta - Rev Cancer VL - 1871 UR - https://doi.org/10.1016/j.bbcan.2019.01.003 DO - 10.1016/j.bbcan.2019.01.003 ID - Gillies2019 ER - TY - JOUR AU - Oldham, W. M. AU - Clish, C. B. AU - Yang, Y. AU - Loscalzo, J. PY - 2015 DA - 2015// TI - Hypoxia-mediated increases in l-2-hydroxyglutarate coordinate the metabolic response to reductive stress JO - Cell Metab VL - 22 UR - https://doi.org/10.1016/j.cmet.2015.06.021 DO - 10.1016/j.cmet.2015.06.021 ID - Oldham2015 ER - TY - JOUR AU - Sonveaux, P. AU - Copetti, T. AU - Saedeleer, C. J. AU - Végran, F. AU - Verrax, J. AU - Kennedy, K. M. PY - 2012 DA - 2012// TI - Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0033418 DO - 10.1371/journal.pone.0033418 ID - Sonveaux2012 ER - TY - JOUR AU - Yin, R. AU - Mao, S. Q. AU - Zhao, B. AU - Chong, Z. AU - Yang, Y. AU - Zhao, C. PY - 2013 DA - 2013// TI - Ascorbic acid enhances tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals JO - J Am Chem Soc VL - 135 UR - https://doi.org/10.1021/ja4028346 DO - 10.1021/ja4028346 ID - Yin2013 ER - TY - JOUR AU - Minor, E. A. AU - Court, B. L. AU - Young, J. I. AU - Wang, G. PY - 2013 DA - 2013// TI - Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.C113.464800 DO - 10.1074/jbc.C113.464800 ID - Minor2013 ER - TY - JOUR AU - Ebata, K. T. AU - Mesh, K. AU - Liu, S. AU - Bilenky, M. AU - Fekete, A. AU - Acker, M. G. PY - 2017 DA - 2017// TI - Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b JO - Epigenetics and Chromatin. VL - 10 UR - https://doi.org/10.1186/s13072-017-0143-3 DO - 10.1186/s13072-017-0143-3 ID - Ebata2017 ER - TY - JOUR AU - Klose, R. J. AU - Yamane, K. AU - Bae, Y. AU - Zhang, D. AU - Erdjument-Bromage, H. AU - Tempst, P. PY - 2006 DA - 2006// TI - The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36 JO - Nature VL - 442 UR - https://doi.org/10.1038/nature04853 DO - 10.1038/nature04853 ID - Klose2006 ER - TY - JOUR AU - Tsukada, Y. I. AU - Fang, J. AU - Erdjument-Bromage, H. AU - Warren, M. E. AU - Borchers, C. H. AU - Tempst, P. PY - 2006 DA - 2006// TI - Histone demethylation by a family of JmjC domain-containing proteins JO - Nature VL - 439 UR - https://doi.org/10.1038/nature04433 DO - 10.1038/nature04433 ID - Tsukada2006 ER - TY - JOUR AU - Lamadema, N. AU - Burr, S. AU - Brewer, A. C. PY - 2019 DA - 2019// TI - Dynamic regulation of epigenetic demethylation by oxygen availability and cellular redox JO - Free Radic Biol Med VL - 131 UR - https://doi.org/10.1016/j.freeradbiomed.2018.12.009 DO - 10.1016/j.freeradbiomed.2018.12.009 ID - Lamadema2019 ER - TY - JOUR AU - Meza, C. A. AU - Favor, J. D. AU - Kim, D. H. AU - Hickner, R. C. PY - 2019 DA - 2019// TI - Endothelial dysfunction: is there a hyperglycemia-induced imbalance of NOX and NOS? JO - Int J Mol Sci VL - 131 ID - Meza2019 ER - TY - JOUR AU - Stefano, G. B. AU - Challenger, S. AU - Kream, R. M. PY - 2016 DA - 2016// TI - Hyperglycemia-associated alterations in cellular signaling and dysregulated mitochondrial bioenergetics in human metabolic disorders JO - Eur J Nutr VL - 55 UR - https://doi.org/10.1007/s00394-016-1212-2 DO - 10.1007/s00394-016-1212-2 ID - Stefano2016 ER - TY - JOUR AU - Guzik, T. J. AU - Mussa, S. AU - Gastaldi, D. AU - Sadowski, J. AU - Ratnatunga, C. AU - Pillai, R. PY - 2002 DA - 2002// TI - Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase JO - Circulation VL - 105 UR - https://doi.org/10.1161/01.CIR.0000012748.58444.08 DO - 10.1161/01.CIR.0000012748.58444.08 ID - Guzik2002 ER - TY - JOUR AU - Miele, C. AU - Paturzo, F. AU - Teperino, R. AU - Sakane, F. AU - Fiory, F. AU - Oriente, F. PY - 2007 DA - 2007// TI - Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol kinase subcellular localization JO - J Biol Chem VL - 282 UR - https://doi.org/10.1074/jbc.M702481200 DO - 10.1074/jbc.M702481200 ID - Miele2007 ER - TY - JOUR AU - Sasaki, N. AU - Yamashita, T. AU - Takaya, T. AU - Shinohara, M. AU - Shiraki, R. AU - Takeda, M. PY - 2008 DA - 2008// TI - Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus JO - Arterioscler Thromb Vasc Biol VL - 28 UR - https://doi.org/10.1161/ATVBAHA.107.160754 DO - 10.1161/ATVBAHA.107.160754 ID - Sasaki2008 ER - TY - JOUR AU - Matsumoto, S. AU - Koshiishi, I. AU - Inoguchi, T. AU - Nawata, H. AU - Utsumi, H. PY - 2003 DA - 2003// TI - Confirmation of superoxide generation via xanthine oxidase in streptozotocin-induced diabetic mice JO - Free Radic Res VL - 37 UR - https://doi.org/10.1080/1071576031000107344 DO - 10.1080/1071576031000107344 ID - Matsumoto2003 ER - TY - JOUR AU - Goldin, A. AU - Beckman, J. A. AU - Schmidt, A. M. AU - Creager, M. A. PY - 2006 DA - 2006// TI - Advanced glycation end products: sparking the development of diabetic vascular injury JO - Circulation VL - 114 UR - https://doi.org/10.1161/CIRCULATIONAHA.106.621854 DO - 10.1161/CIRCULATIONAHA.106.621854 ID - Goldin2006 ER - TY - JOUR AU - Niu, Y. AU - Desmarais, T. L. AU - Tong, Z. AU - Yao, Y. AU - Costa, M. PY - 2015 DA - 2015// TI - Oxidative stress alters global histone modification and DNA methylation JO - Free Radic Biol Med VL - 82 UR - https://doi.org/10.1016/j.freeradbiomed.2015.01.028 DO - 10.1016/j.freeradbiomed.2015.01.028 ID - Niu2015 ER - TY - JOUR AU - Kowluru, R. A. AU - Shan, Y. PY - 2017 DA - 2017// TI - Role of oxidative stress in epigenetic modification of MMP-9 promoter in the development of diabetic retinopathy JO - Graefes Arch Clin Exp Ophthalmol VL - 255 UR - https://doi.org/10.1007/s00417-017-3594-0 DO - 10.1007/s00417-017-3594-0 ID - Kowluru2017 ER - TY - JOUR AU - Kumar, C. AU - Igbaria, A. AU - D’Autreaux, B. AU - Planson, A. G. AU - Junot, C. AU - Godat, E. PY - 2011 DA - 2011// TI - Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control JO - EMBO J VL - 30 UR - https://doi.org/10.1038/emboj.2011.105 DO - 10.1038/emboj.2011.105 ID - Kumar2011 ER - TY - JOUR AU - Zheng, H. AU - Wu, J. AU - Jin, Z. AU - Yan, L. -. J. PY - 2016 DA - 2016// TI - Protein modifications as manifestations of hyperglycemic glucotoxicity in diabetes and its complications JO - Biochem Insights VL - 9 UR - https://doi.org/10.4137/BCI.S36141 DO - 10.4137/BCI.S36141 ID - Zheng2016 ER - TY - JOUR AU - Montecinos, V. AU - Guzmán, P. AU - Barra, V. AU - Villagrán, M. AU - Muñoz-Montesino, C. AU - Sotomayor, K. PY - 2007 DA - 2007// TI - Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione JO - J Biol Chem VL - 282 UR - https://doi.org/10.1074/jbc.M608361200 DO - 10.1074/jbc.M608361200 ID - Montecinos2007 ER - TY - JOUR AU - Camarena, V. AU - Sant, D. W. AU - Huff, T. C. AU - Mustafi, S. AU - Muir, R. K. AU - Aron, A. T. PY - 2017 DA - 2017// TI - CAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool JO - Elife VL - 6 UR - https://doi.org/10.7554/eLife.29750 DO - 10.7554/eLife.29750 ID - Camarena2017 ER - TY - JOUR AU - Deb, D. K. AU - Bao, R. AU - Li, Y. C. PY - 2017 DA - 2017// TI - Critical role of the cAMP-PKA pathway in hyperglycemia-induced epigenetic activation of fibrogenic program in the kidney JO - FASEB J VL - 31 UR - https://doi.org/10.1096/fj.201601116R DO - 10.1096/fj.201601116R ID - Deb2017 ER - TY - JOUR AU - Zhang, Q. AU - Zhao, K. AU - Shen, Q. AU - Han, Y. AU - Gu, Y. AU - Li, X. PY - 2015 DA - 2015// TI - Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6 JO - Nature VL - 525 UR - https://doi.org/10.1038/nature15252 DO - 10.1038/nature15252 ID - Zhang2015 ER - TY - JOUR AU - Wu, H. AU - D’Alessio, A. C. AU - Ito, S. AU - Xia, K. AU - Wang, Z. AU - Cui, K. PY - 2011 DA - 2011// TI - Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells JO - Nature VL - 473 UR - https://doi.org/10.1038/nature09934 DO - 10.1038/nature09934 ID - Wu2011 ER - TY - JOUR AU - Deplus, R. AU - Delatte, B. AU - Schwinn, M. K. AU - Defrance, M. AU - Méndez, J. AU - Murphy, N. PY - 2013 DA - 2013// TI - TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS JO - EMBO J VL - 32 UR - https://doi.org/10.1038/emboj.2012.357 DO - 10.1038/emboj.2012.357 ID - Deplus2013 ER - TY - JOUR AU - Shi, F. T. AU - Kim, H. AU - Lu, W. AU - He, Q. AU - Liu, D. AU - Goodell, M. A. PY - 2013 DA - 2013// TI - Ten-eleven translocation 1 (Tet1) is regulated by o-linked n-acetylglucosamine transferase (ogt) for target gene repression in mouse embryonic stem cells JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M113.460386 DO - 10.1074/jbc.M113.460386 ID - Shi2013 ER - TY - JOUR AU - Chen, Q. AU - Chen, Y. AU - Bian, C. AU - Fujiki, R. AU - Yu, X. PY - 2013 DA - 2013// TI - TET2 promotes histone O-GlcNAcylation during gene transcription JO - Nature. VL - 493 UR - https://doi.org/10.1038/nature11742 DO - 10.1038/nature11742 ID - Chen2013 ER - TY - JOUR AU - Hasegawa, N. AU - Oshima, M. AU - Sashida, G. AU - Matsui, H. AU - Koide, S. AU - Saraya, A. PY - 2017 DA - 2017// TI - Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome JO - Leukemia VL - 31 UR - https://doi.org/10.1038/leu.2016.268 DO - 10.1038/leu.2016.268 ID - Hasegawa2017 ER - TY - JOUR AU - Neri, F. AU - Incarnato, D. AU - Krepelova, A. AU - Rapelli, S. AU - Pagnani, A. AU - Zecchina, R. PY - 2013 DA - 2013// TI - Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells JO - Genome Biol VL - 14 UR - https://doi.org/10.1186/gb-2013-14-8-r91 DO - 10.1186/gb-2013-14-8-r91 ID - Neri2013 ER - TY - JOUR AU - Vella, P. AU - Scelfo, A. AU - Jammula, S. G. AU - Chiacchiera, F. AU - Williams, K. AU - Cuomo, A. PY - 2013 DA - 2013// TI - Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells JO - Mol Cell VL - 49 UR - https://doi.org/10.1016/j.molcel.2012.12.019 DO - 10.1016/j.molcel.2012.12.019 ID - Vella2013 ER - TY - JOUR AU - Issad, T. AU - Kuo, M. S. PY - 2008 DA - 2008// TI - O-GlcNAc modification of transcription factors, glucose sensing and glucotoxicity JO - Trends Endocrinol Metab VL - 19 UR - https://doi.org/10.1016/j.tem.2008.09.001 DO - 10.1016/j.tem.2008.09.001 ID - Issad2008 ER - TY - JOUR AU - Luo, B. AU - Soesanto, Y. AU - McClain, D. A. PY - 2008 DA - 2008// TI - Protein modification by O-linked GlcNAc reduces angiogenesis by inhibiting Akt activity in endothelial cells JO - Arterioscler Thromb Vasc Biol VL - 28 UR - https://doi.org/10.1161/ATVBAHA.107.159533 DO - 10.1161/ATVBAHA.107.159533 ID - Luo2008 ER - TY - JOUR AU - Akimoto, Y. AU - Kreppel, L. K. AU - Hirano, H. AU - Hart, G. W. PY - 2001 DA - 2001// TI - Hyperglycemia and the O-GlcNAc transferase in rat aortic smooth muscle cells: elevated expression and altered patterns of O-GlcNAcylation JO - Arch Biochem Biophys VL - 389 UR - https://doi.org/10.1006/abbi.2001.2331 DO - 10.1006/abbi.2001.2331 ID - Akimoto2001 ER - TY - JOUR AU - Dhliwayo, N. AU - Sarras, M. P. AU - Luczkowski, E. AU - Mason, S. M. AU - Intine, R. V. PY - 2014 DA - 2014// TI - Parp inhibition prevents ten-eleven translocase enzyme activation and hyperglycemia-induced DNA demethylation JO - Diabetes VL - 63 UR - https://doi.org/10.2337/db13-1916 DO - 10.2337/db13-1916 ID - Dhliwayo2014 ER - TY - JOUR AU - Ciccarone, F. AU - Klinger, F. G. AU - Catizone, A. AU - Calabrese, R. AU - Zampieri, M. AU - Bacalini, M. G. PY - 2012 DA - 2012// TI - Poly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0046927 DO - 10.1371/journal.pone.0046927 ID - Ciccarone2012 ER - TY - JOUR AU - Wu, D. AU - Hu, D. AU - Chen, H. AU - Shi, G. AU - Fetahu, I. S. AU - Wu, F. PY - 2018 DA - 2018// TI - Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer JO - Nature VL - 559 UR - https://doi.org/10.1038/s41586-018-0350-5 DO - 10.1038/s41586-018-0350-5 ID - Wu2018 ER - TY - JOUR AU - Brauchle, M. AU - Yao, Z. AU - Arora, R. AU - Thigale, S. AU - Clay, I. AU - Inverardi, B. PY - 2013 DA - 2013// TI - Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0060549 DO - 10.1371/journal.pone.0060549 ID - Brauchle2013 ER - TY - JOUR AU - Cheng, M. B. AU - Zhang, Y. AU - Cao, C. Y. AU - Zhang, W. L. AU - Zhang, Y. AU - Shen, Y. F. PY - 2014 DA - 2014// TI - Specific phosphorylation of histone demethylase KDM3A determines target gene expression in response to heat shock JO - PLoS Biol VL - 12 UR - https://doi.org/10.1371/journal.pbio.1002026 DO - 10.1371/journal.pbio.1002026 ID - Cheng2014 ER - TY - JOUR AU - Baba, A. AU - Ohtake, F. AU - Okuno, Y. AU - Yokota, K. AU - Okada, M. AU - Imai, Y. PY - 2011 DA - 2011// TI - PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B JO - Nat Cell Biol VL - 13 UR - https://doi.org/10.1038/ncb2228 DO - 10.1038/ncb2228 ID - Baba2011 ER - TY - JOUR AU - Lopez-Candales, A. AU - Hernández Burgos, P. M. AU - Hernandez-Suarez, D. F. AU - Harris, D. PY - 2017 DA - 2017// TI - Linking chronic inflammation with cardiovascular disease: from normal aging to the metabolic syndrome JO - J Nat Sci VL - 3 ID - Lopez-Candales2017 ER - TY - JOUR AU - Montero, D. AU - Walther, G. AU - Pérez-Martin, A. AU - Vicente-Salar, N. AU - Roche, E. AU - Vinet, A. PY - 2013 DA - 2013// TI - Vascular smooth muscle function in type 2 diabetes mellitus: a systematic review and meta-analysis JO - Diabetologia VL - 56 UR - https://doi.org/10.1007/s00125-013-2974-1 DO - 10.1007/s00125-013-2974-1 ID - Montero2013 ER - TY - JOUR AU - Miranda-Gonçalves, V. AU - Lameirinhas, A. AU - Henrique, R. AU - Jerónimo, C. PY - 2018 DA - 2018// TI - Metabolism and epigenetic interplay in cancer: regulation and putative therapeutic targets JO - Front Genet VL - 9 UR - https://doi.org/10.3389/fgene.2018.00427 DO - 10.3389/fgene.2018.00427 ID - Miranda-Gonçalves2018 ER - TY - JOUR AU - Ferrari, A. AU - Longo, R. AU - Silva, R. AU - Mitro, N. AU - Caruso, D. AU - Fabiani, E. PY - 2019 DA - 2019// TI - Epigenome modifiers and metabolic rewiring: new frontiers in therapeutics JO - Pharmacol Ther VL - 193 UR - https://doi.org/10.1016/j.pharmthera.2018.08.008 DO - 10.1016/j.pharmthera.2018.08.008 ID - Ferrari2019 ER - TY - JOUR AU - Langemeijer, S. M. C. AU - Kuiper, R. P. AU - Berends, M. AU - Knops, R. AU - Aslanyan, M. G. AU - Massop, M. PY - 2009 DA - 2009// TI - Acquired mutations in TET2 are common in myelodysplastic syndromes JO - Nat Genet VL - 41 UR - https://doi.org/10.1038/ng.391 DO - 10.1038/ng.391 ID - Langemeijer2009 ER - TY - JOUR AU - Jankowska, A. M. AU - Szpurka, H. AU - Tiu, R. V. AU - Makishima, H. AU - Afable, M. AU - Huh, J. PY - 2009 DA - 2009// TI - Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms JO - Blood VL - 113 UR - https://doi.org/10.1182/blood-2009-02-205690 DO - 10.1182/blood-2009-02-205690 ID - Jankowska2009 ER - TY - JOUR AU - Huang, H. AU - Jiang, X. AU - Li, Z. AU - Li, Y. AU - Song, C. X. AU - He, C. PY - 2013 DA - 2013// TI - TET1 plays an essential oncogenic role in MLL-rearranged leukemia JO - Proc Natl Acad Sci U S A VL - 110 UR - https://doi.org/10.1073/pnas.1310656110 DO - 10.1073/pnas.1310656110 ID - Huang2013 ER - TY - JOUR AU - Couronné, L. AU - Bastard, C. AU - Bernard, O. A. PY - 2012 DA - 2012// TI - TET2 and DNMT3A mutations in human T-cell lymphoma JO - N Engl J Med VL - 366 UR - https://doi.org/10.1056/NEJMc1111708 DO - 10.1056/NEJMc1111708 ID - Couronné2012 ER - TY - JOUR AU - Asmar, F. AU - Punj, V. AU - Christensen, J. AU - Pedersen, M. T. AU - Pedersen, A. AU - Nielsen, A. B. PY - 2013 DA - 2013// TI - Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma JO - Haematologica VL - 98 UR - https://doi.org/10.3324/haematol.2013.088740 DO - 10.3324/haematol.2013.088740 ID - Asmar2013 ER - TY - JOUR AU - Jaiswal, S. AU - Natarajan, P. AU - Silver, A. J. AU - Gibson, C. J. AU - Bick, A. G. AU - Shvartz, E. PY - 2017 DA - 2017// TI - Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease JO - N Engl J Med VL - 377 UR - https://doi.org/10.1056/NEJMoa1701719 DO - 10.1056/NEJMoa1701719 ID - Jaiswal2017 ER - TY - JOUR AU - Johansson, C. AU - Tumber, A. AU - Che, K. H. AU - Cain, P. AU - Nowak, R. AU - Gileadi, C. PY - 2014 DA - 2014// TI - The roles of Jumonji-type oxygenases in human disease JO - Epigenomics VL - 6 UR - https://doi.org/10.2217/epi.13.79 DO - 10.2217/epi.13.79 ID - Johansson2014 ER - TY - JOUR AU - Bheda, P. AU - Schneider, R. PY - 2014 DA - 2014// TI - Epigenetics reloaded: the single-cell revolution JO - Trends Cell Biol VL - 24 UR - https://doi.org/10.1016/j.tcb.2014.08.010 DO - 10.1016/j.tcb.2014.08.010 ID - Bheda2014 ER - TY - JOUR AU - Vora, S. AU - Tuttle, M. AU - Cheng, J. AU - Church, G. PY - 2016 DA - 2016// TI - Next stop for the CRISPR revolution: RNA-guided epigenetic regulators JO - FEBS J VL - 283 UR - https://doi.org/10.1111/febs.13768 DO - 10.1111/febs.13768 ID - Vora2016 ER - TY - JOUR AU - Lyko, F. AU - Brown, R. PY - 2005 DA - 2005// TI - DNA methyltransferase inhibitors and the development of epigenetic cancer therapies JO - J Natl Cancer Inst VL - 97 UR - https://doi.org/10.1093/jnci/dji311 DO - 10.1093/jnci/dji311 ID - Lyko2005 ER - TY - JOUR AU - Wagner, J. M. AU - Hackanson, B. AU - Lubbert, M. AU - Jung, M. PY - 2010 DA - 2010// TI - Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy JO - Clin Epigenetics VL - 1 UR - https://doi.org/10.1007/s13148-010-0012-4 DO - 10.1007/s13148-010-0012-4 ID - Wagner2010 ER -