Table 1 Clinical and pathological characteristics of patients with HBV-related diseases
From: The signature of HBV-related liver disease in peripheral blood mononuclear cell DNA methylation
Variable | CHB (n = 24) | LC (n = 14) | DLC( n = 10) | P value |
|---|---|---|---|---|
Age (mean ± SD) | 42.5 ± 6.4 | 43.1 ± 7.2 | 41.3 ± 10.0 | 0.848 |
Gender | 0.953 | |||
Male/female | 16 (66.7%)/8 | 10 (71.4%)/4 | 7 (70.0%)/3 | |
Smoking | 0.181 | |||
No | 12 (50%) | 5 (35.7%) | 4 (40.0%) | |
Infrequent | 7 | 2 | 3 | |
Heavy | 5 | 7 | 3 | |
Alcohol | ||||
No | 15 (62.5%) | 9 (64.3%) | 8 (80.0%) | 0.181 |
Infrequent | 7 | 1 | 2 | |
Heavy | 2 | 4 | 0 | |
TBIL (μmol/L) | 25.63 ± 25.87 | 41.75 ± 46.23 | 70.04 ± 105.96 | 0.133 |
AST (U/L) | 127.76 ± 182.01 | 332.8 ± 576.45 | 76.2 ± 103.7 | 0.131 |
ALT ((U/L)) | 206.03 ± 319.22 | 524.14 ± 956.423 | 73.09 ± 117.38 | 0.130 |
APRI (mean ± SD) | 77.75 ± 109.58 | 269.08 ± 475.83 | 91.53 ± 71.21 | 0.108 |
FIB4 (mean ± SD) | 2.15 ± 1.42 | 3.63 ± 4.54 | 4.95 ± 3.31 | 0.054 |
HBsAg positive/negative | 23 (100%)/0 (a) | 12 (85.7%)/2 | 9 (100%)/0 (b) | 0.083 |
Anti-HBs positive/negative | 1 (4.16%)/22 | 2 (14.29%)/12 | 0 (0%)/9 | 0.291 |
HBeAg positive/negative | 16 (69.56%)/7 | 6 (45.85%)/8 | 2 (22.22%)/7 | 0.034 |
Anti-HBe positive/negative | 10 (43.47)/13 | 8 (57.14)/6 | 6 (66.67%)/3 | 0.447 |
Anti-HBc positive/negative | 23 (100%)/0 | 14 (100%)/0 | 9 (100%)/0 | NA |
Fibrosis | ||||
S1 | 10 | |||
S2 | 9 | |||
S3 | 5 | |||
S3-4 | 4 | |||
S4 | 10 | 10 | ||