Table 2 Adverse childhood experience and DNA methylation age acceleration
Exposure | Unadjusted mean difference in DNA methylation age acceleration, years (± 95% CI) | Adjusteda mean difference in DNA methylation age acceleration, years (± 95% CI) | ||
|---|---|---|---|---|
Girls | Boys | Girls | Boys | |
Count of ACEs | Â | Â | Â | Â |
 None | 0 | 0 | 0 | 0 |
 One | 0.26 (− 0.86, 1.39) | − 0.75 (− 1.79, 0.28) | 0.32 (− 0.81, 1.45) | − 0.48 (− 1.56, 0.60) |
 Two or three | 0.69 (− 0.35, 1.73) | − 0.75 (− 1.73, 0.23) | 0.68 (− 0.42, 1.78) | − 0.30 (− 1.37, 0.78) |
 Four or more | 1.65 (0.40, 2.89)b | − 0.51 (− 1.64, 0.63) | 1.65 (0.25, 3.04)b | − 0.11 (− 1.48, 1.26) |
Individual ACE exposure | Â | Â | Â | Â |
 Bullying | 0.42 (− 0.63, 1.47) | − 0.77 (− 1.70, 0.16) | 0.30 (− 0.79, 1.39) | − 0.61 (− 1.63, 0.40) |
 Emotional abuse | 0.96 (− 0.01, 1.94) | − 0.49 (− 1.40, 0.42) | 1.20 (0.15, 2.26)b | − 0.31 (− 1.34, 0.71) |
 Emotional neglect | − 0.23 (− 1.24, 0.79) | 0.77 (− 0.14, 1.68) | − 0.45 (− 1.53, 0.64) | 0.31 (− 0.69, 1.30) |
 Parent mental health problem | 0.92 (0.11, 1.73)b | − 0.60 (− 1.34, 0.13) | 0.91 (− 0.01, 1.83) | − 0.21 (− 1.05, 0.64) |
 Parent convicted | 0.95 (− 0.40, 2.30) | − 0.12 (− 1.37, 1.13) | 0.56 (− 1.00, 2.12) | − 0.15 (− 1.51, 1.21) |
 Parental separation | 0.85 (− 0.15, 1.86) | 0.19 (− 0.63, 1.02) | 0.90 (− 0.29, 2.10) | 0.62 (− 0.34, 1.58) |
 Physical abuse | 1.29 (0.18, 2.41)b | − 0.05 (− 1.07, 0.97) | 1.22 (0.06, 2.38)b | 0.04 (− 1.11, 1.19) |
 Sexual abuse | 1.04 (− 0.84, 2.92) | − 0.48 (− 3.17, 2.20) | 1.29 (− 0.71, 3.30) | − 0.75 (− 3.67, 2.17) |
 Household substance abuse | 0.82 (− 0.52, 2.16) | 0.36 (− 0.71, 1.44) | 0.72 (− 0.78, 2.22) | 0.43 (− 0.78, 1.65) |
 Violence in household | 0.19 (− 0.82, 1.20) | 0.26 (− 0.69, 1.20) | − 0.15 (− 1.28, 0.99) | 0.72 (− 0.35, 1.79) |