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Table 4 Associations between methylation score and BMI

From: The association of DNA methylation with body mass index: distinguishing between predictors and biomarkers

Time pointsNUnadjusted for current BMI/birthweightAdjusted for current BMI/birthweight
Effect sizeCIp valueAdjusted R-squared1Effect sizeCIp value
Model: Earlier methylation score predicting later BMI2
 Methylation score at birth predicting BMI in childhood830− 0.03− 0.18, 0.130.72− 0.0004− 0.07− 0.22, 0.070.36
 Methylation score at birth predicting BMI in adolescence7120.06− 0.25, 0.360.70− 0.001− 0.05− 0.35, 0.250.73
 Methylation score in childhood predicting BMI in adolescence7620.410.13, 0.690.0040.0050.13− 0.07, 0.340.20
 Antenatal methylation score predicting BMI in middle-age7650.800.44, 1.171.92E−050.020.19− 0.06, 0.440.13
Model: Earlier birthweight or BMI predicting later methylation score3
 Birthweight predicting methylation score in childhood814− 0.0001− 0.0002, 0.000040.170.003− 0.0002− 0.0003, − 0.000060.006
 Birthweight predicting methylation score in adolescence8120.000003− 0.0001, 0.00010.960.002− 0.00008− 0.0002, 0.000050.22
 BMI in childhood predicting methylation score in adolescence8910.090.06, 0.123.05E−090.020.060.04, 0.091.52E−06
 Antenatal BMI predicting methylation score in middle-age8510.070.05, 0.081.42E−160.060.050.03, 0.055.48E−11
  1. 1Adjusted R-squared obtained from model with only the methylation score and no other covariates
  2. 2From model adjusting for age (except at birth), sex (where applicable), sample type (where applicable) and cell type proportions (B cell, CD4T, CD8T, Gran, Mono and NK). Units are standard deviation in DNA methylation score per kg/m2
  3. 3From model adjusting for age (except at birth), sex (where applicable), sample type (where applicable) and cell type proportions (B cell, CD4T, CD8T, Gran, Mono and NK). Units are kg/m2 per standard deviation in DNA methylation score for all models not including birthweight, where the units for these models are grams per standard deviation in DNA methylation score