Table 5 Multivariable association of different factors with DNAm ages in 450K dataset

Whole blood

Sex (male)

− 0.19 (1.22)

0.88

− 1.54 (0.88)

0.09

− 2.08 (1.66)

0.22

1.43 (0.77)

0.07

Cohort (primary)

0.93 (1.71)

0.59

0.33 (1.23)

0.79

− 0.15 (2.33)

0.95

0.04 (1.07)

0.97

Group (intensive)

1.25 (3.89)

0.75

2.67 (2.81)

0.35

1.42 (5.30)

0.79

3.40 (2.44)

0.17

Age (years)

1.08 (0.09)

4.76E−16

1.03 (0.07)

1.13E−20

1.05 (0.12)

2.96E−11

0.84 (0.06)

1.92E−19

T1D Duration (months)

0.015 (0.014)

0.29

0.009 (0.010)

0.37

0.002 (0.019)

0.9

0.006 (0.009)

0.49

Stimulated C-peptide (pmol/ml)*

− 5.11 (5.97)

0.40

− 1.56 (4.31)

0.72

− 4.78 (8.12)

0.56

4.56 (3.75)

0.23

Time-weighted HbA1c (%)†

0.70 (0.98)

0.48

0.64 (0.71)

0.37

0.58 (1.34)

0.67

1.08 (0.62)

0.09

Monocyte

Sex (male)

2.61 (1)

1.18E−2

− 0.51 (0.91)

0.58

− 2.64 (1.62)

0.11

1.3 (0.81)

0.11

Cohort (primary)

− 1.2 (1.49)

0.42

− 0.95 (1.36)

0.49

− 0.98 (2.42)

0.69

0.21 (1.2)

0.86

Group (intensive)

− 0.45 (1.87)

0.81

1.36 (1.7)

0.43

2.58 (3.03)

0.39

0.94 (1.5)

0.53

Age (years)

− 0.21 (0.08)

1.16E−2

− 0.2 (0.07)

9.46E−3

0.92 (0.13)

5.50E−09

− 0.20 (0.07)

4.18E−3

T1D Duration (months)

− 0.01 (0.01)

0.32

− 0.01 (0.01)

0.29

− 0.02 (0.02)

0.31

− 0.01 (0.01)

0.49

Stimulated C-peptide (pmol/ml)*

− 13.05 (5.25)

1.62E−2

− 5.59 (4.78)

0.25

− 14.48 (8.51)

0.09

1.07 (4.23)

0.80

Time-weighted HbA1c (%)†

0.55 (0.71)

0.45

0.45 (0.65)

0.49

0.59 (1.15)

0.61

0.55 (0.57)

0.34