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Table 5 Multivariable association of different factors with DNAm ages in 450K dataset

From: DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes

 Pan-tissueSkin & BloodDNAmDNAm
FactorBeta (SE)pBeta (SE)pBeta (SE)pBeta (SE)p
Whole blood        
Sex (male)− 0.19 (1.22)0.88− 1.54 (0.88)0.09− 2.08 (1.66)0.221.43 (0.77)0.07
Cohort (primary)0.93 (1.71)0.590.33 (1.23)0.79− 0.15 (2.33)0.950.04 (1.07)0.97
Group (intensive)1.25 (3.89)0.752.67 (2.81)0.351.42 (5.30)0.793.40 (2.44)0.17
Age (years)1.08 (0.09)4.76E−161.03 (0.07)1.13E−201.05 (0.12)2.96E−110.84 (0.06)1.92E−19
T1D Duration (months)0.015 (0.014)0.290.009 (0.010)0.370.002 (0.019)0.90.006 (0.009)0.49
Stimulated C-peptide (pmol/ml)*− 5.11 (5.97)0.40− 1.56 (4.31)0.72− 4.78 (8.12)0.564.56 (3.75)0.23
Time-weighted HbA1c (%)†0.70 (0.98)0.480.64 (0.71)0.370.58 (1.34)0.671.08 (0.62)0.09
Monocyte        
Sex (male)2.61 (1)1.18E−2− 0.51 (0.91)0.58− 2.64 (1.62)0.111.3 (0.81)0.11
Cohort (primary)− 1.2 (1.49)0.42− 0.95 (1.36)0.49− 0.98 (2.42)0.690.21 (1.2)0.86
Group (intensive)− 0.45 (1.87)0.811.36 (1.7)0.432.58 (3.03)0.390.94 (1.5)0.53
Age (years)− 0.21 (0.08)1.16E−2− 0.2 (0.07)9.46E−30.92 (0.13)5.50E−09− 0.20 (0.07)4.18E−3
T1D Duration (months)− 0.01 (0.01)0.32− 0.01 (0.01)0.29− 0.02 (0.02)0.31− 0.01 (0.01)0.49
Stimulated C-peptide (pmol/ml)*− 13.05 (5.25)1.62E−2− 5.59 (4.78)0.25− 14.48 (8.51)0.091.07 (4.23)0.80
Time-weighted HbA1c (%)†0.55 (0.71)0.450.45 (0.65)0.490.59 (1.15)0.610.55 (0.57)0.34
  1. Cell counts (B, CD4T, CD8T, natural killer, eosinophil, and monocyte) were also included in the multivariable whole blood analysis
  2. *Stimulated C-peptide at DCCT eligibility
  3. †Time-weighted HbA1c from DCCT baseline to monocyte DNAm measurement