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Table 4 In vitro HDAC-inhibitory activity of MAKV-8 and derived compounds

From: Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells

Compounds

IC50 values against total HDAC activity (nM)

MAKV-6

1050 ± 220

MAKV-7

22,000 ± 25,200

MAKV-8

5.8 ± 3.8

MAKV-10

> 100,000

MAKV-12

> 100,000

  1. Data are presented as the mean ± standard deviation of the concentration inhibiting 50% (IC50) of the HDAC activity. Values were calculated from at least three independent experiments or two independent experiments for MAKV-10 and MAKV-12
  2. HDAC histone deacetylase