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Table 3 EC50 values of MAKV-8 and SAHA towards acetylated targets

From: Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells

Target

EC50 (μM)

MAKV-8

SAHA

Acetyl α-tubulin

12.1 ± 0.9

1.9 ± 0.8

Acetyl histone H4

5.9 ± 1.4

2.6 ± 0.2

  1. Data are presented as the mean ± standard deviation of the effective concentration that induces half-maximal acetylation of protein targets (EC50). Values were calculated after western blot quantification from at least three independent experiments. Concentrations of compounds near the EC50 values have been used for subsequent experiments
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