Fig. 1

DNA methylation outlier burden in Generation Scotland, LBC1921, and LBC1936. Distribution of log10(outlier burden) in Generation Scotland (black, blue contour shapes indicating data density) and in the four LBC1936 waves (orange) and three LBC1921 waves (yellow). a Linear regression lines in Generation Scotland (blue) and in the LBC1921 and LBC1936 (red) to model the association of log10(Outlier Burden) ~ age. b Fitted values for the regression of log10(outlier burden) ~ age with random factor batch and cell proportions fit to the mean