Table 2 DM genes for cytokine/chemokines and their receptor in early RA
Gene Symbol | Naive cells | Memory cells | Monocytes |
|---|---|---|---|
Interleukin family | |||
Cluster | IL6, IL12A, IL13, IL21, IL25, IL31, IL34, IL36G, IL1RAPL2, IL5RA, IL6R, IL10RA, IL12RB1, IL15RA, IL17RC, IL17RE, IL17REL, IL27RA | IL1B, IL6, IL12A, IL15, IL17F, IL17D, IL24, IL37, IL1R2, IL4R, IL6R, IL12RB1, IL15RA, IL17RB, IL17RC, IL17RD, IL17REL, IL20RB, IL21RAS1 | IL16, IL37, IL1RN IL17RC |
Isolated CpG | IL1B, IL5, IL10, IL15, IL16, IL17C, IL17D, IL19, IL25, IL36B, IL17RA, IL18RAP, IL18BP, IL1R1, IL1R2, IL1RN, IL2RA, IL2RB | IL17RA | IL12 |
Tumour necrosis growth factor family | |||
Cluster | TNF, TNFAIP8, TNFSF10, TNFSF12, TNFSF14, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFRSF8, TNFRSF10B, TNFRSF13B, | TNFRSF10C, TNFAIP8, TNFAIP8L3,TNFAIP8L1, TNFRSF9, TNFRSF10B, TNFRSF18, TNFRSF19, TNFRSF25 | TNFAIP2, TNFAIP3, TNFRSF18, TNFRSF19, TNFRSF25 |
Isolated CpG | TNFSF4, TNFSF10, TNFSF12, TNFRSF10A | TNFRSF13B, TNFRSF13C | TNFRSF1B |
Interferon family | |||
Cluster | IFNA2, IFNGR2 | IFNGR2, IFNGR1 | |
Isolated CpG | IFNL4 | ||
Transforming growth factor family | |||
Cluster | TGFBR1, TGFBR2, TGFBR3 | TGFB3 TGFB1, TGFBR2, TGFBR3, | TGFB1, TGFB2AS1 |
Isolated CpG | TGFA, TGFB2-AS1 | TGFBR3L | TGFA |
Chemokine families | |||
Cluster | CCL5, CCL16, CCL25, CCL27, CXCL12 CCR3, CCR5, CCR7, CCR9,CCRL2, CXCR4 | CXCL2,CXCL5 | CCL24, CXCL3, CXCL12, CCR3, CCR9 |
Isolated CpG | CCL2, CCL8, CCL20, CCL24, CXCL11 CXCR1, CXCR5 | CCL23, CCL25, CCL28, CXCL1, CXCL3, CXCL11, CXCL14, CXCL12, CXCL16, CCR3, CCR6, CCR9, CCR10, CCRL2, CXCR1, CXCR2, CXCR4 | CCL3, CXCL1, CXCL16, CCR7, CXCR1, CXCR4 |