Fig. 3

STRING analysis. The Final STRING model includes genes symbol/proteins from the LIST-3 and some manually added genes as suggested by the program when present on Table 2 and LIST-1/2 and, if generating many associations in the network (3 grey gene bubbles). The network analysis displays 3 main JAK1/STATs nodes, an inflammatory node associating IL1R/IL6-IL6R/JAK1/STAT3 signalling (green), a second node for JAK1/STAT2 linked to interferon signalling related genes (orange), and a third centred on IL2R/IL15R/JAK1/STAT5 (dark blue). Many other associations were suggested in relation with IL6, including TNF family (purple), the IL10R and DNA-methylation related genes and targets (HDAC and other in yellow). An IL17/IL25 loop (duck green) was more directly related to JAK1 signalling. Additional genes (forming a STAT4 node) were omitted for simplicity