TY - JOUR AU - Lawrence, Mitchell G. AU - Pidsley, Ruth AU - Niranjan, Birunthi AU - Papargiris, Melissa AU - Pereira, Brooke A. AU - Richards, Michelle AU - Teng, Linda AU - Norden, Sam AU - Ryan, Andrew AU - Frydenberg, Mark AU - Stirzaker, Clare AU - Taylor, Renea A. AU - Risbridger, Gail P. AU - Clark, Susan J. PY - 2020 DA - 2020/03/18 TI - Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer JO - Clinical Epigenetics SP - 48 VL - 12 IS - 1 AB - Prostate cancer changes the phenotype of cells within the stromal microenvironment, including fibroblasts, which in turn promote tumour progression. Functional changes in prostate cancer-associated fibroblasts (CAFs) coincide with alterations in DNA methylation levels at loci-specific regulatory regions. Yet, it is not clear how these methylation changes compare across CAFs from different patients. Therefore, we examined the consistency and prognostic significance of genome-wide DNA methylation profiles between CAFs from patients with different grades of primary prostate cancer. SN - 1868-7083 UR - https://doi.org/10.1186/s13148-020-00836-2 DO - 10.1186/s13148-020-00836-2 ID - Lawrence2020 ER -