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Fig. 7 | Clinical Epigenetics

Fig. 7

From: SEPT9_v2, frequently silenced by promoter hypermethylation, exerts anti-tumor functions through inactivation of Wnt/β-catenin signaling pathway via miR92b-3p/FZD10 in nasopharyngeal carcinoma cells

Fig. 7

SEPT9_v2 decreased the expression of FZD10 through altering the miR-92b-3p level. a The duplex formation between human wild-type (WT) FZD10 3′-UTR and has-miR-92b-3p predicted from the TargetScan. b miR-92b-3p expression level was detected in stably transfected cell lines by qPCR. c The regulation of miR-92b-3p on WT and MT of FZD10 3′-UTR was detected by luciferase assay in HONE1 and HNE1 cells transfected with miR-NC or miR-92b-3p inhibitor oligo. d Effect of miR-92b-3p inhibitor transfection on proliferation in HONE1 and HNE1 cells via MTS assay. All values are presented as the mean ± SD of at least three independent experiments. SD, standard deviation. *p < 0.05, **p < 0.01, ***p < 0.001

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Clinical Epigenetics

ISSN: 1868-7083

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