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Table 6 Sensitivity, Specificity, PPV, and NPV at optimal cutoffs with AUC regarding tumor size (1.1–2 cm)

From: Ultrasensitive DNA hypermethylation detection using plasma for early detection of NSCLC: a study in Chinese patients with very small nodules

Gene

Sensitivity

Specificity

PPV

NPV

AUC

95% CI

CDO1

72%

88%

93%

59%

0.80

0.73–0.88

TAC1

70%

70%

83%

52%

0.69

0.60–0.79

SOX17

65%

93%

95%

55%

0.82

0.75–0.89

HOXA7

61%

77%

85%

48%

0.72

0.63–0.81

CDO1, TAC1, SOX17

73%

93%

96%

62%

0.91

0.87–0.97

CDO1, SOX17, HOXA7

74%

93%

96%

63%

0.92

0.87–0.96

  1. Cancer, n = 92; control, n = 43