Ultrasensitive DNA hypermethylation detection using plasma for early detection of NSCLC: a study in Chinese patients with very small nodules

Table 4 Performance of gene methylation panel in the prediction of early stage lung cancer

Gene	Sensitivity	Specificity	PPV	NPV	AUC	95% CI
Clinical predictors alone	81%	47%	75%	56%	0.70	0.65–0.79
Clinical predictors + CDO1, TAC1, SOX17	93%	63%	83%	82%	0.90	0.86–0.93
Clinical Predictors + CDO1, SOX17, HOXA7	91%	79%	89%	82%	0.94	0.91–0.96

AUC, area under the curve (in the ROC curves); 95% CI, 95 % confidence interval

ISSN: 1868-7083