Fig. 5

The CHD4/NuRD complex regulates complement gene expression. a Gene Set Enrichment Analysis (GSEA) analysis was performed to identify the pathways altered in CHD4 high_expression HCC samples compared to CHD4 low_expression samples. b Venn diagram to show the altered pathways common to all of the six subunits of the NuRD complex which are overexpressed and correlated with poor prognosis in HCC. c GSEA enrichment score curves to show that the complement and coagulation cascades are downregulated in high_expression HCC samples for all of the six subunits. d qRT-PCR analyses were performed to examine the effect of CHD4 knockdown on complement gene expression in HCC cells