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Table 2: Multivariable regression analysis of SIRT1 DNA methylation level (total tissue samples)

From: DNA hypermethylation of sirtuin 1 (SIRT1) caused by betel quid chewing—a possible predictive biomarker for malignant transformation

Variables

B

Standard error

Beta

t

p value

Analysis I

 

 Age

0.102

0.123

0.076

0.833

1.000

 Sex (male 1, female 2)

0.456

4.057

0.011

0.112

1.000

 BQ chewers OSCC vs healthy controls

31.497

3.939

0.782

7.997

0.000

Analysis II

 

 Age

0.081

0.114

0.098

0.708

1.000

 Sex

2.474

3.536

0.094

0.700

1.000

 BQ non-chewers OSCC vs healthy controls

5.391

1.774

0.419

3.039

0.012

Analysis III

 

 Age

0.066

0.151

0.053

0.435

1.000

 Sex

2.619

4.783

0.072

0.548

1.000

 BQ chewers OSCC vs BQ non-chewers OSCC

21.005

4.806

0.587

4.370

0.000

  1. Values in italics represent statistical significance (p < 0.05); p value is calculated using Bonferroni adjustment
  2. B unstandardized coefficients, Beta standardized coefficients, BQ betel quid, OSCC oral squamous cell carcinoma