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Table 2 EWAS CpG-alcohol consumption associations p < 9.4 × 10−8

From: Replication and expansion of epigenome-wide association literature in a black South African population

ProbeID

Location

Gene

Region

β

SE

p

% Variance explained

Χ2

p value

cg13153796a

14:101405628

SNORD113-6

TSS1500

− 6.78E–04

8.45E–05

2.2E–11

29.4 (38.4)

3.8E–12

cg00712390a

17:79373624

BAHCC1

1stExon

8.08E–04

1.14E–04

9.7E–10

37.5 (47.0)

5.6E–18

cg05706661

7:36134301

LOC101928618

TSS1500

− 1.05E–03

1.51E–04

2.0E–09

17.6 (57.1)

6.7E–12

cg24252287a

17:40250379

  

1.48E–04

2.21E–05

4.8E–09

36.5 (41.8)

7.7E–15

cg12177743a

11:113185079

TTC12

TSS200

1.59E–04

2.41E–05

7.5E–09

13.4 (23.4)

2.8E–05

cg19323439

17:9136232

NTN1

Body

5.06E–04

7.93E–05

1.9E–08

14.1 (59.0)

2.1E–08

cg19683675a

5:142077712

FGF1

TSS200

− 1.13E–03

1.78E–04

2.0E–08

35.1 (43.6)

2.7E–15

cg08333974

12:1956337

CACNA2D4

Body

− 1.24E–03

1.95E–04

2.2E–08

25.8 (38.3)

8.3E–12

cg12325997

15:59280148

RNF111

1stExon

9.84E–05

1.57E–05

3.2E–08

10.5 (58.4)

9.4E–08

cg19642811

13:95453039

LOC101927284

Body

− 6.02E–04

9.64E–05

3.4E–08

19.3 (37.3)

2.3E–08

cg06943216

8:102683096

  

− 1.33E–03

2.13E–04

3.5E–08

17.5 (33.9)

4.3E–08

cg26187237a

2:217498574

IGFBP2

1stExon

4.19E–04

6.72E–05

3.6E–08

15.5 (53.0)

2.2E–09

cg16358446a

1:1534984

  

8.10E–05

1.31E–05

4.4E–08

43.8 (52.4)

1.9E–21

cg08724692

6:133646558

EYA4

Body

− 6.26E–04

1.03E–04

6.4E–08

10.3 (43.4)

1.2E–06

cg08035774

9:136600662

SARDH

5′UTR

− 1.12E–03

1.85E–04

7.5E–08

23.6 (32.8)

6.3E–10

cg18780412a

3:179755086

PEX5L

TSS1500

6.36E–04

1.06E–04

8.6E–08

27.0 (33.5)

6.4E–11

cg15942324

1:38482118

UTP11L

Body

− 6.63E–04

1.10E–04

8.8E–08

23.3 (33.2)

3.4E–09

cg25278025

2:103378026

TMEM182

TSS1500

5.99E–04

9.98E–05

8.8E–08

15.4 (26.0)

5.0E–06

cg22572934b

5:173171061

LINC01484

Body

− 1.21E–03

2.02E–04

9.3E–08

13.3 (24.3)

5.5E–05

  1. Model: methylation ~ alcohol consumption (g/d) + age + BMI + smoking + cell counts + surrogate variables
  2. a450K probes
  3. bProbe that should be interpreted with caution owing to the presence of genomic variance at probe measurement site [17]
  4. The percentage variance explained reflects the added value of alcohol consumption to the variance in CpG methylation, reported as percentage explained by alcohol as an added exposure (percentage variance explained by the total model). Χ2 p value = Chi-square p value when the regression models with and without alcohol consumption are compared