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Table 1 List of 37 enriched genes belonging to the DNA binding category (GO:0003677)

From: DNA methylation changes in Down syndrome derived neural iPSCs uncover co-dysregulation of ZNF and HOX3 families of transcription factors

GroupGene nameCGI position (hg19)State# DMPDEG
HOX proteinsHOXD4chr2:177014948-177015214Hyper2 
HOXD3chr2:177029413-177029941Hyper1Up
MEIS1chr2:66672431-66673636Hypo3 
HOXA3chr7:27163819-27164098Hyper3Up
HOXB3chr17:46631800-46632212Hyper1Up
HIST1 proteinsHIST1H3Achr6:26020671-26021125Hyper1 
HIST1H4Achr6:26020671-26021125Hyper3 
HIST1H2BKchr6:27107138-27107394Hyper1 
HIST1H2ALchr6:27833120-27833406Hyper4 
HIST1H1Bchr6:27835190-27835461Hyper1 
ZNF transcription factorsPRDM16chr1:3102540-3103352Hypo2 
ZNF512chr2:27805754-27806078Hyper1Down
ZNF518Bchr4:10458129-10459353Hyper1Down
CXXC5chr5:139040819-139041028Hypo1Up
FEZF1chr7:121943867-121944538Hypo3 
TRPS1chr8:116660432-116660747Hyper1 
ZNF263chr16:3332472-3333847Hypo1 
ZNF397OSchr18:32847284-32848130Hyper1 
ZNF441chr19:11877720-11878280Hypo1Up
ZNF69chr19:11998804-11999131Hypo10Up
ZNF700chr19:12035899-12036433Hypo9Up
ZNF763chr19:12076029-12076366Hypo9 
ZNF529chr19:37095680-37096589Hyper1 
Transcription factorsSP5chr2:171569877-171573904Hypo2 
SP3chr2:174828330-174830617Hypo1 
NEUROD6chr7:31375845-31376542Hyper1 
PAX5chr9:36985986-36986924Hypo1Up
CREBZFchr11:85374872-85376234Hypo1 
SIM2chr21:38079941-38081833Hypo1 
DNA-binding proteinsCOLEC11chr2:3683029-3683290Hypo1 
WRNIP1chr6:2765203-2766775Hyper2 
JRKchr8:143750759-143751448Hypo2 
FBXO21chr12:117627650-117628488Hypo2Up
KDM2Bchr12:121975028-121976140Hyper1 
POLEchr12:133249979-133250243Hypo1Down
WNT1chr12:49371690-49375550Hyper2 
SMC1Bchr22:45809191-45809953Hypo2 
  1. Genes annotated to a CGI+ with at least 1 DMP. Columns denote groups of encoded proteins, position of CGIs, methylation state, number of DMPs and differential expression of genes (DEG; Up upregulated, Down downregulated; p < 0.05)