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Fig. 1 | Clinical Epigenetics

Fig. 1

From: DNA methylation changes in Down syndrome derived neural iPSCs uncover co-dysregulation of ZNF and HOX3 families of transcription factors

Fig. 1

Overview of the study. Neural iPSC derivatives from two Down syndrome subjects with full trisomy 21 (T21) and two healthy (euploid) subjects were harvested at two stages of differentiation for DNA-methylation analysis of CpGs queried by probes on the 450K array (Illumina). Differentially methylated probes (DMPs) associated with T21 neural lines, and at two stages of differentiation, were assigned to CpG islands (CGIs) and genes. Subsequent enrichment analysis identified 37 genes that were subject to expression analysis

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Clinical Epigenetics

ISSN: 1868-7083

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