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Fig. 3 | Clinical Epigenetics

Fig. 3

From: KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies

Fig. 3

Epigenetic craniofacial enhancer analysis. Epigenetic analysis of conserved craniofacial enhancer element hs1431 shown as Genome Browser tracks of aligned indicated ChIP Seq signal peaks. Y-axis indicates coverage by estimated fragments normalized to millions of reads mapped generated from next generation sequencing. Experiments are from mouse 4 days old embryoid bodies (MLL3−/−;MLL4flox/flox) [48] and e11.5 embryonic mouse facial tissu e[128]. Data analyzed are publically available from Gene Expression Omnibus database (accession numbers GSE50534 and GSE49413). Data analysis, peak calling, and visualization were performed in BioWardrobe [130] with GRCm38/mm10 genome build

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