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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Genome-wide assessment of DNA methylation in mouse oocytes reveals effects associated with in vitro growth, superovulation, and sexual maturity

Fig. 5

a SeqMonk screenshot of the DNA methylation profiles of the CGIs at the locus Sfi1 in chromosome 11. Each color-coded vertical bar represents the methylation value of a differentially methylated CGI. Genes and oocyte mRNA are shown in red or blue depending on their direction of transcription (forward or reverse, respectively). b Box-whisker plot showing the DNA methylation levels at 28 maternally imprinted germline differentially methylated regions (gDMRs) in each replicate. In the plots, the line across the middle of the box shows the median, the upper and lower extremities of the box show the 25th and 75th percentile of the set of data, and the upper and lower black whiskers show the median plus/minus the interquartile (25–75%) range multiplied by 2. Individual points that fall outside this range are shown as filled circles and represent single outlier tiles. c DNA methylation levels at the Nespas-Gnasxl gDMR for each sample. d SeqMonk screenshot of the DNA methylation distribution (100-CpG tiles quantified) in relation to the gene structure of Dnmt1. The data for the replicates is combined into the tracks labeled IFC, SO, SOA, and IV. Each color-coded bar represents the methylation value of a non-overlapping 100-CpG tile. The direction of transcription is represented by the arrows. The promoter of the oocyte transcript is marked with a black bar

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