Epigenome-wide association study of seizures in childhood and adolescence

Clinical Epigenetics

Table 3 Mendelian randomization analysis. Effects of DNA methylation at cg16983916 on non-epilepsy outcomes (PheWAS and candidate outcomes)

Outcome	Reference	N	Beta^a	S.E.	P value (uncorrected)
Weight	UK Biobank^b	336227	0.016	0.009	0.067
Trunk fat-free mass	UK Biobank^b	331030	0.025	0.006	3.73 × 10⁻⁰⁵
Standing height	UK Biobank^b	336474	0.029	0.007	2.90 × 10⁻⁰⁵
Years of schooling	Okbay et al. [46]	182286	0.008	0.008	0.317
Childhood intelligence	Benyamin et al. [47]	12441	0.013	0.051	0.797
Autism	Smoller et al. [48]	29415	− 0.008	0.113	0.946
Fluid intelligence score	UK Biobank^b	108818	0.119	0.036	0.001
College or University degree	UK Biobank^b	334070	0.013	0.004	0.004

ISSN: 1868-7083