Fig. 2From: Epigenome-wide association study of seizures in childhood and adolescencea Miami plot displaying the EWAS results by chromosome in adolescence. Positive values on y-axis indicate -log(p values) of hypermethylated sites, whereas negative values on the y-axis indicate -log(p values) of hypomethylated sites (the sign of the y-axis values has been changed to reflect this). Bonferroni cut-off line in red. b Boxplot of methylation levels at the BDNF-linked CpG cg13974632 (adjusted for covariates). c Causal estimate for the effect of genetic generalized epilepsy on cg13974632 (BDNF). Individual SNP results in black and overall causal estimates in red. d Leave-one-out analysis of the causal estimate for the effect of genetic generalized epilepsy on cg13974632 (BDNF). IVW inverse variance weightedBack to article page