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Table 3 Association between CRTC1 methylation probes and psychotropic induced-early weight gain during the first month of treatment

From: Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients

 

cg21310814 (%)

cg07015183

cg02961385 (%)

cg17006757 (%)

cg22536770 (%)

cg12034943 (%)

Estimate (SE)

p value

Estimate (SE)

p value

Estimate (SE)

p value

Estimate (SE)

p value

Estimate (SE)

p value

Estimate (SE)

p value

Early weight gain1

 

NS

 

NS

 

NS

 

NS

 

NS

− 0.3 (0.2)

0.01

Age

 

NS

 

NS

 

NS

 

NS

− 0.008 (0.006)

0.04

 

NS

Sex

 

NS

 

NS

 

NS

 

NS

 

NS

 

NS

Treatment groups2

 

NS

 

NS

 

NS

 

NS

 

NS

 

NS

Smoking

 

NS

 

NS

 

NS

 

NS

 

NS

 

NS

Treatment duration3

0.05 (0.009)

0.0001

0.03 (0.005)

0.001

0.02 (0.004)

< 0.0001

0.04 (0.008)

0.02

0.01 (0.004)

0.007

 

NS

  1. Multivariable mixed models adjusting for age, sex, psychotropic drug category, smoking status, and treatment duration were fitted for 151 observations (from 78 patients). Models on M values were conducted to determine the p values, whereas models on beta values were conducted to determine the estimates. Validity of multivariable models was verified by plotting residuals against fitted values. Additional multivariable models considering the white blood cell composition were fitted for 68 patients. Neutrophils were significantly associated with cg21310814, cg17006757, and cg12034943 (p < 0.0001, p = 0.003, and p = 0.04). Associations between all CRTC1 probes and variables indicated in this table remained significant when adjusting for white blood cell composition (except for cg17006757). p values in italic are significant
  2. NS non-significant
  3. 1Patients whose weight gain during the first month of treatment was between 0 and 2.5% were considered as controls, whereas patients whose weight gain during the first month of treatment was equal or higher than 5% were considered as cases
  4. 2Psychotropic drugs were categorized into three groups according to their weight gain propensities: amisulpride and aripiprazole were considered as drugs with a low propensity for weight gain, lithium, mirtazapine, quetiapine, and risperidone were considered as drugs with a moderate propensity for weight gain and clozapine, olanzapine, and valproate were considered as having a high risk for inducing weight gain
  5. 3Treatment duration was considered in days
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Clinical Epigenetics

ISSN: 1868-7083

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