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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients

Fig. 1

Schematic representation of the significant CRTC1 methylation sites. The figure is scaled. SNPs associated with methylation sites (i.e., cis-meQTL) are indicated using asterisks. Cis-meQTL: associations between methylation sites and SNPs were extracted from BIOS QTL browser, a public source with available methylation quantitative trait loci (meQTL) data from 3841 Dutch individuals [49]. eQTL: Cis-association data of the influence of SNPs on the expression of nearby genes were extracted from the Genotype-Tissue Expression (GTEx) project, a public source with available expression quantitative trait loci (eQTL) data of 7051 samples from 44 different tissues and for genome-wide genetic variations in the general population (Illumina OMNI 5 M SNP Array) [50]. The functional activity of SNPs was assessed by using the RegulomeDB [51]

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