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Table 1 Baseline characteristics of the severely obese cohort who underwent bariatric surgery

From: The effects of bariatric surgery on clinical profile, DNA methylation, and ageing in severely obese patients

 

Pre-surgery

3 months after the surgery

6 months after the surgery

12 months after the surgery

Mean difference 12 months-baseline (sd)

p value

Sex (females) n, %

26 (65%)

26 (65%)

26 (65%)

26 (65%)

  

Age (years)

45.1 (8.06)

-

-

46.1 (8.06)

  

WHR

1 (0.15)b

1 (0.15)

0.96 (0.13)b

0.97 (0.13)a

− 0.06 (0.13)

0.095

BMI kg/m2

45.5 (9.3)

 

38.3 (9.2)a

35.9 (8.35)

− 9.57 (5.9)

5.1 × 10−13

Fasting glucose mmol/L

6.5 (2.2)

5.7 (1.5)

5.3 (1.1)a

5.2 (1.2)b

− 1.17 (1.8)

1.6 × 10−4

Insulin ulU/L

17.5 (10.5)a

12.2 (8.7)

9.2 (5.5)b

7.3 (4.4)b

− 10.7 (8.3)

1.3 × 10−8

HOMA-IR

5.1 (3.7)a

-

2.4 (1.5)c

1.9 (1.1)c

− 3.9 (3.7)

9.4 × 10−7

HbA1c %

6.5 (1.1)a

6.1 (0.9)

6 (0.7)b

5.9 (0.9)b

− 0.56 (0.8)

0.001

Total cholesterol mmol/L

5.1 (1.1)a

4.6 (0.7)

4.6 (0.8)b

4.5 (1.2)b

− 0.63 (0.8)

2.3 × 10−4

HDL mmol/L

1.1 (0.4)a

1.1 (0.4)

1.1 (0.4)b

1.2 (0.4)b

0.16 (0.3)

0.026

LDL mmol/L

3.2 (1)a

3.0 (0.8)

2.7 (0.8)b

2.7 (1)b

− 0.57 (0.8)

4.1 × 10−4

TG mmol/L

1.4 [1.0, 2.4]a

1.3 [0.9, 1.8]

0.9 [0.8, 1.8]b

1.1 [0.7, 1.5]b

− 0.5 (0.7)

1.4 × 10−6

FFA mmol/L

0.6 (0.3)b

0.6 (0.3)

0.5 (0.2)b

0.5 (0.2)b

− 0.10 (0.34)

0.034

ALAT U/L

23.5 (10.2)a

25.6 (10.8)

27 (20.9)b

24.3 (10.8)b

2.5 (12.1)

0.650

ASAT U/L

22.1 (9.2)a

19.3 (6.7)

22.9 (15)b

17.4 (7.1)b

− 3.7 (11.2)

0.064

CRP mg/L

7.6 [3.2,16.5]a

4.8 [1.6, 11.5]

3.4 [1.7,5.5]c

1.4 [1, 2.9]b

− 4.8 (10)

8.8 × 10−7

  1. Data shown as mean (sd) for normally distributed variables, as median [25%, 75%] for not normally distributed variables and as n (%) for categorical variables, p value is calculated using mixed models
  2. a1–5 NA’s
  3. b6–10 NA’s
  4. c > 10 NA’s