Fig. 5

Difference in target genes by inflammation-induced hypermethylation between young and old gastric mucosae, and enrichment of driver genes in young mucosae. a Plot of the induction levels in young and old gastric mucosae. A total of 13 areas (A2 to M2) were defined based upon the degrees in young and old gastric mucosae. Genomic blocks in area M2 were not methylated by inflammation in young or old gastric mucosae (Δβ values < 0.1). b Heatmap of hypermethylated genomic blocks for three kinds of gastric mucosae. The regions in area D2 were hypermethylated in all HP current young gastric mucosae and one or two of the HP current old gastric mucosae. c Gene expression levels, basal methylation levels, and H3K27me3 frequency for genes in areas A2-D2 and M2. Regions in area D2 had higher expression levels and lower H3K27me3 frequency. d Number of somatic mutations in gastric cancers registered at the COSMIC database and gene expression levels for genes in areas A2-D2. Genes in area D2 were enriched as those with a large number of mutations and high expression levels