Table 3 The results of the scaled number of shared epigenetic mutations calculated from different sets of CpGs in association with age, sex, twin zygosity, and zygosity-age interaction
From: Comprehensive longitudinal study of epigenetic mutations in aging
Covariates | Estimate | Standard error | p value | |
|---|---|---|---|---|
All CpGs (390,894) | Age | 0.019 | 8.59e-3 | 0.026 |
Sex | 0.208 | 0.107 | 0.055 | |
Zygosity (DZ) | − 1.078 | 0.105 | 3.41e-18 | |
Zygosity (DZ) × age | − 0.012 | 0.011 | 0.284 | |
Non-cis-meQTL CpGs (370,234) | Age | 0.025 | 9.17e-3 | 5.98e-03 |
Sex | 0.183 | 0.116 | 0.117 | |
Zygosity (DZ) | − 0.855 | 0.114 | 1.05e-11 | |
Zygosity (DZ) × age | − 0.013 | 0.012 | 0.263 | |
Cis-meQTL CpGs (20,660) | Age | 2.86e-4 | 7.61e-3 | 0.969 |
Sex | 0.194 | 0.107 | 0.071 | |
Zygosity (DZ) | − 1.461 | 1.105 | 8.34e-28 | |
Zygosity (DZ) × age | − 3.77e-3 | 9.64e-3 | 0.696 |