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Table 2 The association between number of epigenetic mutations (log10-transformed) and age from mixed models with confounders

From: Comprehensive longitudinal study of epigenetic mutations in aging

Number of epigenetic mutationsEffect sizes (p values)
Age (year)Sex (Female to male)CD19+ B cells (proportion)1st genetic principal componentSample quality*Cancer diagnosis
Total epigenetic mutations8.29e-03 (1.22e-13)0.0722 (6.33e-03)4.21 (5.06e-23)0.445 (0.0413)0.369 (1.48e-117)0.0697 (0.0139)
Frequent epigenetic mutations6.03e-03 (2.17e-19)-0.0180 (0.33)1.76 (1.37e-12)0.595 (1.28e-04)0.0573 (5.84e-13)0.0478 (0.0164)
Frequent high methylation outliers6.81e-03 (2.09e-17)-0.0314 (0.16)2.09 (2.25e-12)0.750 (7.65e-05)0.0512 (3.58e-08)0.0602 (0.0130)
Frequent low methylation outliers2.82e-03 (1.14e-05)0.0340 (0.057)0.474 (0.046)0.0186 (0.92)0.0888 (8.09e-30)-6.99e-03 (0.71)
  1. *Sample quality was indicated by the log10-transfromed number of CpGs with a detection p value over 0.01