Table 2 The association between number of epigenetic mutations (log10-transformed) and age from mixed models with confounders
From: Comprehensive longitudinal study of epigenetic mutations in aging
Number of epigenetic mutations | Effect sizes (p values) | |||||
|---|---|---|---|---|---|---|
Age (year) | Sex (Female to male) | CD19+ B cells (proportion) | 1st genetic principal component | Sample quality* | Cancer diagnosis | |
Total epigenetic mutations | 8.29e-03 (1.22e-13) | 0.0722 (6.33e-03) | 4.21 (5.06e-23) | 0.445 (0.0413) | 0.369 (1.48e-117) | 0.0697 (0.0139) |
Frequent epigenetic mutations | 6.03e-03 (2.17e-19) | -0.0180 (0.33) | 1.76 (1.37e-12) | 0.595 (1.28e-04) | 0.0573 (5.84e-13) | 0.0478 (0.0164) |
Frequent high methylation outliers | 6.81e-03 (2.09e-17) | -0.0314 (0.16) | 2.09 (2.25e-12) | 0.750 (7.65e-05) | 0.0512 (3.58e-08) | 0.0602 (0.0130) |
Frequent low methylation outliers | 2.82e-03 (1.14e-05) | 0.0340 (0.057) | 0.474 (0.046) | 0.0186 (0.92) | 0.0888 (8.09e-30) | -6.99e-03 (0.71) |