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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Comprehensive longitudinal study of epigenetic mutations in aging

Fig. 6

Comparing the DNA methylation and epigenetic mutation patterns of gene PRDM7 between tumor and normal adjacent tissues. Data were downloaded from TCGA through Wanderer. The cancer types included lung cancer, breast cancer, colorectal cancer, and prostate cancer. a The location of CpGs related to gene PRDM7 in UCSC genome browser. b The methylation levels of CpGs in gene PRDM7. Tumor and normal adjacent tissues had similar methylation levels in the gene promoter, while the methylation levels of tumor tissues in the gene body were significantly lower than normal adjacent tissues. c The proportion of epigenetic mutations in tumor and normal adjacent tissues. Tumor tissues had higher proportions of epigenetic mutations in the gene body, while both tumor and normal adjacent tissues had similar but low proportion of epigenetic mutations in the gene promoter

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