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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Comprehensive longitudinal study of epigenetic mutations in aging

Fig. 1

The number of epigenetic mutations (log10-transformed) increased longitudinally with age in a longitudinal perspective using genome-wide DNA methylation data from repeated whole blood samples collected in the Swedish Adoption/Twin Study of Aging (SATSA; n = 375 participants). The numbers of epigenetic mutations of samples were counted from a total epigenetic mutations (n = 370,234 CpGs, p = 1.22e-13 for association with age), b total epigenetic mutation in individuals with at least 4 measures (p = 1.94e-08 for association with age), c frequent high methylation outliers (HMOs) (n = 969 CpGs, p = 2.09e-17 for association with age), d frequent HMOs in individuals with at least 4 measures (p = 1.07e-10 for association with age), e frequent low methylation outliers (LMOs) (n = 216 CpGs, p = 1.14e-05 for association with age), and f frequent LMOs in individuals with at least 4 measures (p = 5.76e-03 for association with age)

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