Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation

Clinical Epigenetics

Table 2 List of differentially methylated CpGs with FDR-corrected p value < 0.05 in individuals who developed AD dementia in the AgeCoDe study. T2 is a comparison of AD patients (converters) vs controls (non-converters), whereas T1 is the same comparison before conversion to AD dementia. The 6 CpGs exhibiting a similar methylation change in DS and AD patients when compared to controls are highlighted in italic (LogFC: log2 fold change). Regulatory build is according to gene regulation data in Ensembl

	Gene	Regulatory build	logFC	Average	FDR	logFC	Average	FDR	LOGFC	FDR
	Gene	Regulatory build	T2	T2	T2	T1	T1	T1	DS	DS
cg18431127	EPB42	TF binding site	− 0.115	0.452	0.003	0.004	0.468	0.980	0.049	0.016
cg21442773	LYST	Promoter	0.018	0.064	0.003	− 0.003	0.064	0.939	0.091	0.010
cg19695335	ZNF337	Promoter	0.022	0.048	0.004	0.001	0.045	0.974	0.016	0.046
cg13390975	BRIX1	Promoter	0.030	0.052	0.005	0.001	0.048	0.979	0.107	0.001
cg27004669	MN1	Open sea	− 0.113	0.439	0.005	0.017	0.448	0.897	0.048	0.018
cg02625641	ADAM10	Promoter	0.034	0.081	0.009	0.001	0.077	0.978	0.032	0.013
cg15814736	ATL3	Promoter	0.034	0.045	0.009	0.002	0.041	0.953	0.029	0.032
cg11162385	ZNF337	Promoter	0.027	0.071	0.012	0.000	0.068	0.996	0.044	0.014
cg22599005	CYP2W1	CTCF	0.092	0.707	0.036	0.011	0.721	0.954	− 0.045	0.011

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