Table 1 Top 10 differentially methylated CpGs within the T21 IQ-/T21 IQ+ contrast. Positive β differences indicate hypermethylation and negative β differences hypomethylation in the T21 IQ− group in comparison with the T21 IQ+ group
Methylation difference | Average methylation | Adjusted p value | Genomic location | Gene | Region | |
|---|---|---|---|---|---|---|
cg22352474 | 0.07 | 0.06 | 0.002 | chr2: 64371530 | PELI1 | 5′UTR;1stExon |
cg02307184 | 0.24 | 0.20 | 0.119 | chr5: 23821294 | ||
cg05755219 | − 0.20 | 0.84 | 0.161 | chr13: 24386298 | MIPEP | Body |
cg19166616 | 0.13 | 0.12 | 0.161 | chr20: 62259876 | GMEB2 | TSS1500 |
cg13939234 | 0.11 | 0.08 | 0.198 | chr4: 120375997 | ||
cg26950080 | 0.06 | 0.75 | 0.198 | chr16: 31162846 | PRSS36 | TSS1500 |
cg03159409 | − 0.11 | 0.72 | 0.205 | chr12: 124779144 | FAM101A | 5′UTR |
cg14071023 | − 0.26 | 0.78 | 0.205 | chr6: 45901289 | CLIC5 | Body |
cg19442201 | − 0.12 | 0.65 | 0.205 | chr15: 40572550 | ||
cg10584271 | − 0.24 | 0.59 | 0.205 | chr3: 52814643 | ITIH1 | 5′UTR;body |