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Fig. 7 | Clinical Epigenetics

Fig. 7

From: DNMT1 recruited by EZH2-mediated silencing of miR-484 contributes to the malignancy of cervical cancer cells through MMP14 and HNF1A

Fig. 7

MMP14/HNF1A overexpression partly rescues the suppression of the malignant behavior induced by miR-484 in CC cells. Co-transfection with pri-miR-484 and pFlag-MMP14 (MMP14) or pFlag-HNF1A (HNF1A) showed that overexpression of MMP14 or HNF1A partly rescued cell adhesion (a and b), migration (c and d), and invasion (e and f) in HeLa and C33A cells. g and h Western blot showed the protein levels of β-integrin, E-cadherin, and vimentin after transfection with pri-miR-484 and MMP14/HNF1A. All of the experiments were repeated three times. *p < 0.05, **p < 0.01. ***p < 0.001

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Clinical Epigenetics

ISSN: 1868-7083

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