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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNMT1 recruited by EZH2-mediated silencing of miR-484 contributes to the malignancy of cervical cancer cells through MMP14 and HNF1A

Fig. 2

The correlation between DNMT1 downregulation and miR-484 expression. a Genomic bisulfite sequencing revealed the methylation status of CC cells transfected with DNMT1 siRNA and control siRNA. b and c The mRNA level and the promoter activity of miR-484 after knockdown of DNMT1 in CC cells were determined by RT-qPCR (b) and luciferase reporter assay (c). d The mRNA level of DNMT1 in 20 pairs of CC tissues was measured by RT-qPCR; actin was used for normalization. e The correlation between miR-484 and DNMT1 expression. Error bars indicate the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01,***p < 0.001

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