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Fig. 1 | Clinical Epigenetics

Fig. 1

From: ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer

Fig. 1

The expression levels of ZMYND10 in breast cancer tissues. a Representative images of ZMYND10 IHC staining in breast tumor and tumor-adjacent tissues. b Quantitative real-time PCR (qPCR) analysis of ZMYND10 mRNA expression in paired breast tumor and tumor-adjacent tissue samples. c Box plot of ZMYND10 gene expression for tumor samples stratified according to ER status. d Box plot of ZMYND10 gene expression for tumor samples stratified according to Hu subtypes and PAM50 subtypes. e Box plot of ZMYND10 gene expression for tumor samples stratified according to histological grade. f Low ZMYND10 expression is associated with poor 10-year distant metastasis-free survival (DMFS) and relapse-free survival (RFS) in breast cancer patients. Prognosis data was acquired and analyzed using the Gene expression-based Outcome for Breast cancer Online tool (http://co.bmc.lu.se/gobo) and the Kaplan-Meier Plotter database

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Clinical Epigenetics

ISSN: 1868-7083

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