Fig. 2From: DNA methylation profiles in chronic lymphocytic leukemia patients treated with chemoimmunotherapyEnrichment analysis of the epigenetic burden and relapse changes regarding genomic locations, chromatin states, and transcription factor binding sites. Genomic location enrichment analysis of a the epigenetic burden hypomethylated (green) and hypermethylated (red) CpGs for each CLL case and b the relapse hypomethylated (green) and hypermethylated (red) CpGs for each CLL case. Chromatin states enrichment analysis of c the epigenetic burden hypomethylated (green) and hypermethylated (red) CpGs for each CLL case and d the relapse hypomethylated and hypermethylated (red) CpGs for each CLL case. Each column represents a CLL case, with the cases sorted on x-axis based on the number of DMCpGs per case, from maximum to minimum. Each row represents a genomic element. The red color on heatmap displays the significant enrichment (p < 0.05) in each case for the respective genomic element (ActProm, active promoter; Hete LowSign, heterochromatin low signal; Het Repr, heterochromatin-repressed; PolRepr, polycomb repression; PoisProm, poised promoter; StrEnh1, strong enhancer 1; StrEnh2, strong enhancer 2; Txn_Elong, transcription elongation; Txn_Trans, transcription transition, Wk_Txn, weak transcription; WkEnh, weak enhancer; WkProm, weak promoter. e TFBS analysis of the hypo- and hypermethylated epigenetic burdens and relapse changes revealed significant enrichment for several TFs families (x-axis). The density of heatmap represents the number of patients which showed statistical significant enrichment per TFBS (FDR < 0.05)Back to article page