Table 4 Pubertal exposure analysis in ALSPAC on the factors and CpGs identified in IOW
From: Changes in DNA methylation from pre- to post-adolescence are associated with pubertal exposures
Pubertal exposures | CpG sites | Genes | Est. coeff. | p valueRaw | |
|---|---|---|---|---|---|
BMI5/7 | BMI5/7 × gender$ | cg08770870 | RPH3AL | − 0.018 | 0.465 |
cg19663246 | PDE1C | − 0.002 | 0.932 | ||
BMI5/7 | cg08770870 | RPH3AL | 0.008 | 0.535 | |
cg19663246 | PDE1C | 0.017 | 0.175 | ||
Pubertal events | Female’s age of menarche | cg06271237 | PLAGL1 | 0.004 | 0.619 |
Other factors | Current/Former smoking status (Yes) | cg05575921 | AHRR | − 0.199 | 7.43 × 10−8 |
cg14753356 | IER3 | − 0.099 | 0.010 | ||
cg26703534 | AHRR | − 0.071 | 0.002 | ||
cg24296397 | BSN | − 0.017 | 0.403 | ||
cg08709672 | AVPR1B | − 0.035 | 0.031 | ||
cg16391678 | ITGAL | − 0.092 | 0.003 | ||
cg20295214 | AVPR1B | − 0.004 | 0.896 | ||
cg21241889 | TRAF1 | − 0.029 | 0.137 | ||
cg04885881 | SRM | − 0.033 | 0.236 | ||
cg08109568 | FAN1 | − 0.005 | 0.868 | ||
cg08884752 | SKI | − 0.048 | 0.131 | ||