Changes in DNA methylation from pre- to post-adolescence are associated with pubertal exposures

Clinical Epigenetics

Table 2 The four most statistically significant canonical pathways from IPA

Pathways	Ratio	p value	CpG sites	Genes
Amyotrophic Lateral Sclerosis Signaling	0.081	0.00026	cg01483824	GRIN2D
			cg05404236	*IRS2*
			cg05942459	GRIK2
			cg14029489	PRPH
			cg19318393	CAPN2
			cg20681578	*AKT3*
			cg22562942	NEFM
			cg23786580	HECW1
			cg26746936	GRIK5
G-Protein Coupled Receptor Signaling	0.050	0.0010	cg00456868	CHRM5
			cg01207684	*ADCY9*
			cg01939453	*PDE10A*
			cg02914422	*PDE1C*
			cg05404236	*IRS2*
			cg10273340	*GNAO1*
			cg11701471	OPRK1
			cg11934695	ADRA1D
			cg19908812	NPY1R
			cg20681578	*AKT3*
			cg21213853	GRM2
			cg23817981	CCR4
			cg24540003	*RELA*
Relaxin Signaling	0.057	0.0032	cg01207684	*ADCY9*
			cg01939453	*PDE10A*
			cg02914422	*PDE1C*
			cg05404236	*IRS2*
			cg10273340	*GNAO1*
			cg20681578	*AKT3*
			cg24540003	*RELA*
			cg25599619	GNB1
IL-17A Signaling in Airway Cells	0.077	0.0036	cg05404236	*IRS2*
			cg15053248	MAP3K7
			cg15931839	TRAF3IP2
			cg20681578	AKT3
			cg24540003	*RELA*

[1] Ratio is the number of genes in our list to the number of genes in a pathway [2]. CpGs and genes identified in at least two pathways are in bold font

ISSN: 1868-7083