Table 5 Biomarker performance of HOXD3, RASSF1A and SOX17 promoters’ methylation levels for discrimination among small cell lung carcinoma (SCLC) and non-small cell Lung carcinoma (NSCLC)
Genes | AUC (95 % CI) | p-value | Cut-off value | Sensitivity % (95% CI) | Specificity % (95% CI) | Accuracy % (95% CI) | Positive likelihood ratio (LR+) (95% CI) | Negative likelihood ratio (LR–) (95% CI) |
|---|---|---|---|---|---|---|---|---|
SCLC vs NSCLC | ||||||||
HOXD3me | 0.742 (0.577–0.907) | 0.002 | 1401.1301 | 69 (41–89) | 88 (80–94) | 85 (77–92) | 5.9 (3.0–11.6) | 0.35 (0.17–0.73) |
RASSF1Ame | 0.775 (0.617–0.934) | < 0.001 | 204.8474 | 63 (35–85) | 98 (92–100) | 92 (85–97) | 26.9 (6.5–113.3) | 0.38 (0.20–0.72) |
SOX17me | 0.657 (0.504–0.811) | 0.046 | 30.1876 | 56 (30–80) | 76 (65–84) | 73 (63–81) | 2.3 (1.3–4.1) | 0.58 (0.33–1.02) |
HOXD3me/RASSF1Ame | - | - | - | 75 (48–93) | 88 (80–94) | 86 (78–92) | 6.5 (3.4–12.3) | 0.28 (0.12–0.66) |