TY - STD TI - Pace E, Di Vincenzo S, Ferraro M, Bruno A, Dino P, Bonsignore MR, et al. Carbocysteine counteracts the effects of cigarette smoke on cell growth and on the SIRT1/FoxO3 axis in bronchial epithelial cells. Exp Gerontol 2016;81:119-128. PubMed PMID: 27237816. ID - ref1 ER - TY - JOUR AU - Walters, M. S. AU - De, B. P. AU - Salit, J. AU - Buro-Auriemma, L. J. AU - Wilson, T. AU - Rogalski, A. M. PY - 2014 DA - 2014// TI - Smoking accelerates aging of the small airway epithelium JO - Respir Res VL - 15 UR - https://doi.org/10.1186/s12931-014-0094-1 DO - 10.1186/s12931-014-0094-1 ID - Walters2014 ER - TY - STD TI - Nicita-Mauro V, Lo Balbo C, Mento A, Nicita-Mauro C, Maltese G, Basile G. Smoking, aging and the centenarians. Exp Gerontol 2008;43(2):95-101. PubMed PMID: 17686596. ID - ref3 ER - TY - STD TI - Liu Y, Pleasants RA, Croft JB, Wheaton AG, Heidari K, Malarcher AM, et al. Smoking duration, respiratory symptoms, and COPD in adults aged >/=45 years with a smoking history. Int J Chron Obstruct Pulmon Dis 2015;10:1409-1416. PubMed PMID: 26229460. Pubmed Central PMCID: 4516194. ID - ref4 ER - TY - JOUR AU - Nicita-Mauro, V. AU - Maltese, G. AU - Nicita-Mauro, C. AU - Lasco, A. AU - Basile, G. PY - 2010 DA - 2010// TI - Non smoking for successful aging: therapeutic perspectives JO - Curr Pharm Des VL - 16 UR - https://doi.org/10.2174/138161210790883552 DO - 10.2174/138161210790883552 ID - Nicita-Mauro2010 ER - TY - STD TI - Chien AL, Qi J, Cheng N, Do TT, Mesfin M, Egbers R, et al. Perioral wrinkles are associated with female gender, aging, and smoking: development of a gender-specific photonumeric scale. J Am Acad Dermatol. 2016;74(5):924-930. PubMed PMID: 26803346. ID - ref6 ER - TY - STD TI - Vij N, Chandramani-Shivalingappa P, Van Westphal C, Hole R, Bodas M. Cigarette smoke-induced autophagy impairment accelerates lung aging, COPD-emphysema exacerbations and pathogenesis. Am J Physiol Cell Physiol. 2018;314(1):C73-C87. PubMed PMID: 27413169. Pubmed Central PMCID: 5866380. ID - ref7 ER - TY - STD TI - Gao X, Zhang Y, Breitling LP, Brenner H. Tobacco smoking and methylation of genes related to lung cancer development. Oncotarget. 2016;7(37):59017-59028. PubMed PMID: 27323854. eng. ID - ref8 ER - TY - JOUR AU - Willemse, B. W. M. AU - Postma, D. S. AU - Timens, W. AU - Hacken, N. H. T. PY - 2004 DA - 2004// TI - The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation JO - Eur Respir J VL - 23 UR - https://doi.org/10.1183/09031936.04.00012704 DO - 10.1183/09031936.04.00012704 ID - Willemse2004 ER - TY - STD TI - Tsaprouni LG, Yang TP, Bell J, Dick KJ, Kanoni S, Nisbet J, et al. Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. Epigenetics 2014;9(10):1382-1396. PubMed PMID: 25424692. Pubmed Central PMCID: 4623553. ID - ref10 ER - TY - JOUR AU - Hannum, G. AU - Guinney, J. AU - Zhao, L. AU - Zhang, L. AU - Hughes, G. AU - Sadda, S. PY - 2013 DA - 2013// TI - Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates JO - Mol Cell. VL - 49 UR - https://doi.org/10.1016/j.molcel.2012.10.016 DO - 10.1016/j.molcel.2012.10.016 ID - Hannum2013 ER - TY - STD TI - Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115-R11R. PubMed PMID: 24138928. Epub 10/21. ID - ref12 ER - TY - STD TI - Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Milano). 2018;10(4):573-591. PubMed PMID: 29676998. eng. ID - ref13 ER - TY - JOUR AU - Ambaipudi, S. AU - Cuenin, C. AU - Hernandezvargas, H. AU - Ghantous, A. AU - Calvezkelm, F. L. AU - Kaaks, R. PY - 2016 DA - 2016// TI - Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study JO - Epigenomics VL - 8 UR - https://doi.org/10.2217/epi-2016-0001 DO - 10.2217/epi-2016-0001 ID - Ambaipudi2016 ER - TY - STD TI - Quach A, Levine ME, Tanaka T, Lu AT, Chen BH, Ferrucci L, et al. Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. Aging (Milano) 2017;9(2):419-446. PubMed PMID: 28198702. ID - ref15 ER - TY - STD TI - Horvath S, Erhart W, Brosch M, Ammerpohl O, von Schönfels W, Ahrens M, et al. Obesity accelerates epigenetic aging of human liver. Proc Natl Acad Sci U S A. 2014;111(43):15538-15543. PubMed PMID: 25313081. Epub 10/13. ID - ref16 ER - TY - STD TI - Zannas AS, Arloth J, Carrillo-Roa T, Iurato S, Röh S, Ressler KJ, et al. Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling. Genome Biol. 2015;16:266. PubMed PMID: 26673150. UR - https://www.ncbi.nlm.nih.gov/pubmed/26673150 ID - ref17 ER - TY - STD TI - Horvath S, Ritz BR. Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients. Aging (Milano) 2015;7(12):1130-1142. PubMed PMID: 26655927. ID - ref18 ER - TY - STD TI - Horvath S, Garagnani P, Bacalini MG, Pirazzini C, Salvioli S, Gentilini D, et al. Accelerated epigenetic aging in Down syndrome. Aging cell. 2015;14(3):491-495. PubMed PMID: 25678027. Epub 02/09. ID - ref19 ER - TY - STD TI - Vidal-Bralo L, Lopez-Golan Y, Mera-Varela A, Rego-Perez I, Horvath S, Zhang Y, et al. Specific premature epigenetic aging of cartilage in osteoarthritis. Aging (Milano) 2016;8(9):2222-2231. PubMed PMID: 27689435. ID - ref20 ER - TY - STD TI - Levine ME, Lu AT, Bennett DA, Horvath S. Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning. Aging (Milano) 2015;7(12):1198-1211. PubMed PMID: 26684672. UR - https://www.ncbi.nlm.nih.gov/pubmed/26684672 ID - ref21 ER - TY - STD TI - Hsu CC, Leu YW, Tseng MJ, Lee KD, Kuo TY, Yen JY, et al. Functional characterization of Trip10 in cancer cell growth and survival. J Biomed Sci. 2011;18:12. PubMed PMID: 21299869. Pubmed Central PMCID: 3044094. ID - ref22 ER - TY - STD TI - McLoughlin KJ, Pedrini E, MacMahon M, Guduric-Fuchs J, Medina RJ. Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies. Front Med (Lausanne). 2019;6. ID - ref23 ER - TY - STD TI - Donlon TA, Morris BJ, Chen R, Masaki KH, Allsopp RC, Willcox DC, et al. Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity. J Gerontol A Biol Sci Med Sci 2018;73(11):1459-1464. PubMed PMID: 29300832. Pubmed Central PMCID: 6175033. ID - ref24 ER - TY - STD TI - Di Donato N, Jean YY, Maga AM, Krewson BD, Shupp AB, Avrutsky MI, et al. Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant. Am J Hum Genet. 2016;99(5):1117-1129. PubMed PMID: 27773430. Pubmed Central PMCID: 5097945. ID - ref25 ER - TY - STD TI - Li Y, Xiao X, Ji X, Liu B, Amos CI. RNA-seq analysis of lung adenocarcinomas reveals different gene expression profiles between smoking and nonsmoking patients. Tumour Biol 2015 Nov;36(11):8993-9003. PubMed PMID: 26081616. Pubmed Central PMCID: 4674426. ID - ref26 ER - TY - STD TI - Rapisarda V, Borghesan M, Miguela V, Encheva V, Snijders AP, Lujambio A, et al. Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-beta Pathway. Cell Rep 2017;18(10):2480-2493. PubMed PMID: 28273461. Pubmed Central PMCID: 5357738. ID - ref27 ER - TY - STD TI - Yin J, Yang L, Xie Y, Liu Y, Li S, Yang W, et al. Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy. Nat Commun 2018;9(1):1752. PubMed PMID: 29717119. Pubmed Central PMCID: 5931527. ID - ref28 ER - TY - JOUR AU - Bruneau, B. G. AU - Nemer, G. AU - Schmitt, J. P. AU - Charron, F. AU - Robitaille, L. AU - Caron, S. PY - 2001 DA - 2001// TI - A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease JO - Cell VL - 106 UR - https://doi.org/10.1016/S0092-8674(01)00493-7 DO - 10.1016/S0092-8674(01)00493-7 ID - Bruneau2001 ER - TY - STD TI - Lengi AJ, Corl BA. Bovine brain region-specific stearoyl-CoA desaturase expression and fatty acid composition. Lipids 2015 Jun;50(6):555-563. PubMed PMID: 25899038. ID - ref30 ER - TY - STD TI - Geng RQ, Yuan C, Chen YL. Molecular cloning and expression analysis of prostaglandin E receptor 2 gene in cashmere goat (Capra hircus) skin during hair follicle development. Anim Biotechnol 2014;25(2):98-107. PubMed PMID: 24555795. ID - ref31 ER - TY - STD TI - Prall WC, Czibere A, Jager M, Spentzos D, Libermann TA, Gattermann N, et al. Age-related transcription levels of KU70, MGST1 and BIK in CD34+ hematopoietic stem and progenitor cells. Mech Ageing Dev 2007;128(9):503-510. PubMed PMID: 17714764. ID - ref32 ER - TY - JOUR AU - Rigotti, N. A. PY - 2013 DA - 2013// TI - Smoking cessation in patients with respiratory disease: existing treatments and future directions JO - Lancet Respir Med VL - 1 UR - https://doi.org/10.1016/S2213-2600(13)70063-8 DO - 10.1016/S2213-2600(13)70063-8 ID - Rigotti2013 ER - TY - STD TI - Philibert R, Hollenbeck N, Andersen E, McElroy S, Wilson S, Vercande K, et al. Reversion of AHRR Demethylation Is a Quantitative Biomarker of Smoking Cessation. Front Psychiatry 2016;7:55. PubMed PMID: 27092088. Pubmed Central PMCID: 4822186. ID - ref34 ER - TY - STD TI - Langevin SM, Eliot M, Butler RA, Cheong A, Zhang X, McClean MD, et al. CpG island methylation profile in non-invasive oral rinse samples is predictive of oral and pharyngeal carcinoma. Clin Epigenetics. 2015;7:125. PubMed PMID: 26635906. Pubmed Central PMCID: 4668652. ID - ref35 ER - TY - STD TI - Jessen WJ, Borgerding MF, Prasad GL. Global methylation profiles in buccal cells of long-term smokers and moist snuff consumers. Biomarkers. 2018 Nov;23(7):625-639. PubMed PMID: 29771158. ID - ref36 ER - TY - STD TI - Vucic EA, Chari R, Thu KL, Wilson IM, Cotton AM, Kennett JY, et al. DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways. Am J Respir Cell Mol Biol 2014;50(5):912-922. PubMed PMID: 24298892. Pubmed Central PMCID: 4068945. ID - ref37 ER - TY - STD TI - Clifford RL, Fishbane N, Patel J, MacIsaac JL, McEwen LM, Fisher AJ, et al. Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD. Clin Epigenetics 2018;10:32. PubMed PMID: 29527240. Pubmed Central PMCID: 5838860. ID - ref38 ER - TY - STD TI - Kaz AM, Wong CJ, Varadan V, Willis JE, Chak A, Grady WM. Global DNA methylation patterns in Barrett's esophagus, dysplastic Barrett's, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use. Clin Epigenetics 2016;8:111. PubMed PMID: 27795744. Pubmed Central PMCID: 5082363. ID - ref39 ER - TY - STD TI - Sundar IK, Yin Q, Baier BS, Yan L, Mazur W, Li D, et al. DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD. Clin Epigenetics 2017;9:38. PubMed PMID: 28416970. Pubmed Central PMCID: 5391602. ID - ref40 ER - TY - STD TI - Robles AI, Arai E, Mathe EA, Okayama H, Schetter AJ, Brown D, et al. An Integrated Prognostic Classifier for Stage I Lung Adenocarcinoma Based on mRNA, microRNA, and DNA Methylation Biomarkers. J Thorac Oncol 2015;10(7):1037-1048. PubMed PMID: 26134223. Pubmed Central PMCID: 4493931. ID - ref41 ER - TY - STD TI - Kajiura K, Masuda K, Naruto T, Kohmoto T, Watabnabe M, Tsuboi M, et al. Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma. Oncotarget. 2016;8(2):2890-2905. PubMed PMID: 27926516. eng. ID - ref42 ER - TY - STD TI - Kettunen E, Hernandez-Vargas H, Cros MP, Durand G, Le Calvez-Kelm F, Stuopelyte K, et al. Asbestos-associated genome-wide DNA methylation changes in lung cancer. Int J Cancer. 2017;141(10):2014-2029. PubMed PMID: 28722770. ID - ref43 ER -