Patients (%, 95% CIs) with AE (maximum Grade CTCAE v4.0) | ||||
---|---|---|---|---|
Adverse event | Grade 1 - 2 | Grade 3 | Grade 4 | Total of patients with AE |
Hematological AEs | ||||
Platelet count decreased | 6 (12.0) | 15 (30.0) | 16 (32.0) | 37 (74.0, 59.7 - 85.4 ) |
Anemia | 8 (16.0) | 2 (4.0) | 10 (20.0, 10.0 - 33.7) | |
White blood cell decreased | 1 (2.0) | 8 (16.0) | 9 (18.0, 8.6 - 31.4 ) | |
Non-hematological AEs | ||||
Fatigue | 9 (18.0) | 7 (14.0) | 16 (32.0, 19.5 - 46.7) | |
Nausea | 11 (22.0) | 4 (8.0) | 15 (30.0, 17.9 - 44.6) | |
Diarrhea | 11 (22.0) | 1 (2.0) | 12 (24.0, 13.1 - 38.2) | |
Vomiting | 8 (16.0) | 2 (4.0) | 10 (20.0, 10.0 - 33.7) | |
Alopecia | 9 (18.0) | 9 (18.0, 8.6 - 31.4) | ||
Weight decreased | 5 (10.0) | 3 (6.0) | 8 (16.0, 7.2 - 29.1) | |
Decreased appetite | 5 (10.0) | 2 (4.0) | 7 (14.0, 5.8 - 26.7) | |
Headache | 5 (10.0) | 1 (2.0) | 6 (12.0, 4.5 - 24.3) | |
Blood creatinine increased | 5 (10.0) | 5 (10.0, 3.3 - 21.8) | ||
Alanine aminotransferase increased | 2 (4.0) | 2 (4.0) | 4 (8.0, 2.2 - 19.2) | |
Blood lactate dehydrogenase increased | 4 (8.0) | 4 (8.0, 2.2 - 19.2) | ||
Constipation | 4 (8.0) | 4 (8.0, 2.2 - 19.2) | ||
Dry skin | 4 (8.0) | 4 (8.0, 1.3 - 16.5) | ||
Cough | 3 (6.0) | 3 (6.0, 1.3 - 16.5) | ||
Hypermagnesemia | 3 (6.0) | 3 (6.0, 1.3 - 16.5) | ||
Pyrexia | 3 (6.0) | 3 (6.0, 1.3 - 16.5) |