DLT | Patients (%) with DLT per dose level (mg/m2/day) | Total sum of DLTs | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
 | 130 | 180 | 230 | 280 | 330 | 380 | 430 | 480 | 530 | 580 | |
Hematological DLTs | |||||||||||
 Platelet count decreased |  | 6 (12%) | 8 (16%) | 13 (26%) | 6 (12%) | 4 (8%) | 4 (8%) | 3 (6%) | 4 (8%) | 3 (6%) | 52a |
 White blood cell decreased |  | 1 (2%) | 3 (6%) | 2 (4%) | 2 (4%) | 1 (2%) | 1 (2%) |  |  | 1 (2%) | 11 |
 Anemia |  | 1 (2%) |  |  |  |  |  |  |  | 1 (2%) | 2 |
Non-hematological DLTs | |||||||||||
 Fatigue | 1 (2%) | 1 (2%) | 1 (2%) | 1 (2%) |  |  | 1 (2%) | 1 (2%) |  | 1 (2%) | 7 |
 Hyponatremia |  | 2 (4%) |  |  | 1 (2%) |  | 1 (2%) |  |  |  | 4 |
 Nausea | 1 (2%) | 1 (2%) | 1 (2%) | 1 (2%) |  |  |  |  |  |  | 4 |
 Alanine aminotransferase increased |  | 1 (2%) | 2 (4%) |  |  |  |  |  |  |  | 3 |
 Decreased appetite | 1 (2%) | 1 (2%) | 1 (2%) |  |  |  |  |  |  |  | 3 |
 Hypermagnesemia |  |  |  | 1 (2%) | 1 (2%) |  | 1 (2%) |  |  |  | 3 |
 Abdominal pain upper | 1 (2%) | 1 (2%) |  |  |  |  |  |  |  |  | 2 |
 Febrile infection |  |  |  | 1 (2%) |  |  |  |  |  | 1 (2%) | 2 |
 Vomiting |  |  | 1 (2%) | 1 (2%) |  |  |  |  |  |  | 2 |
 Weight decreased |  |  | 1 (2%) |  |  |  |  |  |  | 1 (2%) | 2 |
 Abdominal pain |  |  |  | 1 (2%) |  |  |  |  |  |  | 1 |
 Aggression |  | 1 (2%) |  |  |  |  |  |  |  |  | 1 |
 Apathy |  | 1 (2%) |  |  |  |  |  |  |  |  | 1 |
 Hypokalemia |  |  | 1 (2%) |  |  |  |  |  |  |  | 1 |
 Loss of personal independence in daily activities |  |  |  |  |  |  | 1 (2%) |  |  |  | 1 |