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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia

Fig. 3

Low levels of cytokine expression at baseline define a cohort with favorable outcome. a Heat map of baseline concentrations (Gehan u-score). MTD group, < 280 = MTD reached was below 280 mg/m2, > = 280 = MTD reached was equal to or above 280 mg/m2, not reached = MTD was not reached; Best Response: PD: best response progressive disease; PR/SD: best response partial response or stable disease; not assessable: best response not assessable. b PFS and OS Kaplan-Meier plot according to cytokine cluster high and low. c PFS and OS Kaplan-Meier plot according to cytokine cluster high, intermediate (int), and low in cluster 2

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Clinical Epigenetics

ISSN: 1868-7083

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