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Table 3 The DNA methylation of cervical scrapings in discriminating normal and ovarian carcinoma patients

From: Ovarian cancer detection by DNA methylation in cervical scrapings

Gene set

Training set

Testing set

Cut-off

Se. (%)

Sp. (%)

AUC (95% CI)

Se.(%, 95% CI)

Sp. (%, 95% CI)

AUC (95% CI)

Single gene

AMPD3

3.10

64.5

90.3

0.80 (0.68–0.91)

71.4 (47.8–88.7)

71.4 (47.8–88.7)

0.83 (0.70–0.95)

AOX1

1.29

64.5

93.6

0.79 (0.67–0.91)

66.7 (43.0–85.4)

100 (83.9–100)

0.85 (0.73–0.97)

MEGF1

4.47

54.8

87.1

0.68 (0.54–0.82)

NRN1

0.46

61.3

96.8

0.78 (0.67–0.90)

57.1 (34.0–78.2)

100 (83.9–100)

0.88

(0.79–0.98)

TBX15

6.37

74.3

83.9

0.82 (0.71–0.92)

76.2 (52.8–91.8)

76.2 (52.8–91. 8)

0.85

(0.74–0.97)

Gene combinationa

AMPD3 + TBX15

− 0.30

87.1

74.2

0.85 (0.75–0.95)

90.5 (69.6–98.8)

52.4 (29.8–74.3)

0.88 (0.79–0.98)

AOX1 + TBX15

0.85

74.2

90.3

0.85 (0.74–0.95)

71.4 (47.8–88.7)

85.7 (63.66–97.0)

0.88 (0.79–0.98)

NRN1 + TBX15

1.92

77.4

83.9

0.85 (0.75–0.95)

57.1 (34.0–78.2)

95.2 (76.2–99.98)

0.90 (0.81–0.99)

AMPD3 + NRN1 + TBX15

0.73

80.7

83.9

0.87 (0.77–0.97)

81.0 (58.1–94.6)

84.2 (60.4–96.9)

0.91 (0.82–1.0)

AOX1 + NRN1 + TBX15

1.93

77.4

83.9

0.85 (0.75–0.95)

57.1 (34.0–78.2)

95.2 (76.2–99.9)

0.90 (0.81–0.99)

AOX1 + AMPD3 + TBX15

0.37

77.4

87.1

0.85 (0.75–0.96)

57.1 (34.0–78.2)

94.7 (74.0–99.9)

0.89 (0.80–0.99)

  1. Se., sensitivity; Sp. Specificity; AUC, area under the curve of receiver operating characteristic; CI, confidence interval; OC, ovarian carcinoma
  2. aThe accuracy of gene combinations was estimated by the logistics regression model