Table 3 The DNA methylation of cervical scrapings in discriminating normal and ovarian carcinoma patients
From: Ovarian cancer detection by DNA methylation in cervical scrapings
Gene set | Training set | Testing set | |||||
|---|---|---|---|---|---|---|---|
Cut-off | Se. (%) | Sp. (%) | AUC (95% CI) | Se.(%, 95% CI) | Sp. (%, 95% CI) | AUC (95% CI) | |
Single gene | |||||||
 AMPD3 | 3.10 | 64.5 | 90.3 | 0.80 (0.68–0.91) | 71.4 (47.8–88.7) | 71.4 (47.8–88.7) | 0.83 (0.70–0.95) |
 AOX1 | 1.29 | 64.5 | 93.6 | 0.79 (0.67–0.91) | 66.7 (43.0–85.4) | 100 (83.9–100) | 0.85 (0.73–0.97) |
 MEGF1 | 4.47 | 54.8 | 87.1 | 0.68 (0.54–0.82) | – | – | – |
 NRN1 | 0.46 | 61.3 | 96.8 | 0.78 (0.67–0.90) | 57.1 (34.0–78.2) | 100 (83.9–100) | 0.88 (0.79–0.98) |
 TBX15 | 6.37 | 74.3 | 83.9 | 0.82 (0.71–0.92) | 76.2 (52.8–91.8) | 76.2 (52.8–91. 8) | 0.85 (0.74–0.97) |
Gene combinationa | |||||||
 AMPD3 + TBX15 | − 0.30 | 87.1 | 74.2 | 0.85 (0.75–0.95) | 90.5 (69.6–98.8) | 52.4 (29.8–74.3) | 0.88 (0.79–0.98) |
 AOX1 + TBX15 | 0.85 | 74.2 | 90.3 | 0.85 (0.74–0.95) | 71.4 (47.8–88.7) | 85.7 (63.66–97.0) | 0.88 (0.79–0.98) |
 NRN1 + TBX15 | 1.92 | 77.4 | 83.9 | 0.85 (0.75–0.95) | 57.1 (34.0–78.2) | 95.2 (76.2–99.98) | 0.90 (0.81–0.99) |
 AMPD3 + NRN1 + TBX15 | 0.73 | 80.7 | 83.9 | 0.87 (0.77–0.97) | 81.0 (58.1–94.6) | 84.2 (60.4–96.9) | 0.91 (0.82–1.0) |
 AOX1 + NRN1 + TBX15 | 1.93 | 77.4 | 83.9 | 0.85 (0.75–0.95) | 57.1 (34.0–78.2) | 95.2 (76.2–99.9) | 0.90 (0.81–0.99) |
 AOX1 + AMPD3 + TBX15 | 0.37 | 77.4 | 87.1 | 0.85 (0.75–0.96) | 57.1 (34.0–78.2) | 94.7 (74.0–99.9) | 0.89 (0.80–0.99) |