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Table 2 Summary DNA methylation level of candidate genes in training and testing sets

From: Ovarian cancer detection by DNA methylation in cervical scrapings

Sample set Diagnosis No. AMPD3 AOX1 MEGF1 NRN1 TBX15
Training set ΔCp median ± (95% CI) Normal 31 3.8 ± (3.5–4.0) 2.0 ± (1.8–2.7) 5.8 ± (5.3–6.5) 2.3 ± (1.6–2.9) 7.6 ± (6.8–8.1)
OC 31 2.7 ± (1.8–3.2)*** 1.0 ± (0.3–1.5)* ** 4.4 ± (3.8–5.7)* 0.1 ± (−0.1 − 1.9)*** 5.1 ± (4.2–6.2)***
Testing set ΔCp median ± (95% CI) Normal 21 3.6 ± (3.0–4.1)a 2.8 ± (2.0–3.5) 4.2 ± (3.2–5.3) 7.6 ± (6.7–8.0)
OC 21 2.0 ± (1.1–3.1)*** 0.9 ± (0.2–2.0)* ** 0.4 ± (− 0.0 − 1.9)*** 4.9 ± (3.7–6.3)***
  1. No., number of cases; CI, confidence interval; OC, ovarian carcinoma
  2. P values were compared with normal and disease using two-tailed Mann–Whitney U test. ***< 0.001; *< 0.05
  3. aThe number of qualified values is 19