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Table 2 Summary DNA methylation level of candidate genes in training and testing sets

From: Ovarian cancer detection by DNA methylation in cervical scrapings

Sample set

Diagnosis

No.

AMPD3

AOX1

MEGF1

NRN1

TBX15

Training set ΔCp median ± (95% CI)

Normal

31

3.8 ± (3.5–4.0)

2.0 ± (1.8–2.7)

5.8 ± (5.3–6.5)

2.3 ± (1.6–2.9)

7.6 ± (6.8–8.1)

OC

31

2.7 ± (1.8–3.2)***

1.0 ± (0.3–1.5)* **

4.4 ± (3.8–5.7)*

0.1 ± (−0.1 − 1.9)***

5.1 ± (4.2–6.2)***

Testing set ΔCp median ± (95% CI)

Normal

21

3.6 ± (3.0–4.1)a

2.8 ± (2.0–3.5)

–

4.2 ± (3.2–5.3)

7.6 ± (6.7–8.0)

OC

21

2.0 ± (1.1–3.1)***

0.9 ± (0.2–2.0)* **

–

0.4 ± (− 0.0 − 1.9)***

4.9 ± (3.7–6.3)***

  1. No., number of cases; CI, confidence interval; OC, ovarian carcinoma
  2. P values were compared with normal and disease using two-tailed Mann–Whitney U test. ***< 0.001; *< 0.05
  3. aThe number of qualified values is 19